Sweat and Hair: Online Interventions for Improving Physical Activity in African-American Women.

OBJECTIVE: To evaluate the efficacy of an informational website in improving patient knowledge on hair care and exercise. DESIGN: Pre- and post-exposure surveys, focusing on exercise and hair care practices, were administered to subjects after 1 h of browsing a dermatologist-designed hair care and exercise website. SETTING: Winston Salem State University, a historically Black university in North Carolina, USA. PARTICIPANTS: 22 African-American women (AAW) aged between 18 and 54 years. MEASUREMENTS: The outcome measures of the study include patient demographics, hair care practices, knowledge of hair/care disorders, exercise habits, and website feedback. RESULTS: There were 22 women enrolled in the study with 95% identifying as African-American. The average age was 28 ± 12 years. A total of 80% (16/20) of subjects reported exercising less than 150 min per week, and 36% of these patients reported modifying their hairstyle to accommodate physical activity. 85% learned new information about hair and scalp disorders from the educational material on the website, and 81% had increased understanding of their hair health. 91% reported that they would return to the website. CONCLUSION: An informational website can be an effective tool to educate AAW on hair and scalp disease, as well as appropriate hair care practices and fitness goals.

Dermatosis Papulosa Nigra: A Quality of Life Survey Study.

Background: Dermatosis papulosa nigra (DPN) is a skin condition characterized by pigmented sessile and pedunculated papules on the body, particularly on the face and other sun-exposed areas, that can cause cosmetic disfigurement and varying degrees of distress and psychosocial concern among patients. Objective: We sought to evaluate the effect of DPN on quality of life (QoL). Methods: A 39-item questionnaire was administered to 50 African-American (AA) adults, 48 women and two men, with an average age of 51.7 years and visible DPN lesions at a dermatology clinic. We collected demographic information, family history, prior treatment, as well as type(s), frequency, duration of lesions, and attitudes about lesions. Dermatologic QoL (DLQI) survey scores were used to quantify the effect that DPN had on QoL. RESULTS: Most subjects reported lesions on the face (86%); 49 percent reported between 10 to 30 lesions on the body. The average age of diagnosis was 44.7 years (±15.51 years). Further, 84 percent of subjects reported having a firstdegree relative with DPN. Most patients reported little to no symptoms from their DPN (82%), while 36 percent had previously visited a physician due to their DPN. Electrocautery and cryosurgery were the most common methods of DPN removal. All subjects who had their DPN lesions removed reported improvement in the appearance of their skin. The average (standard deviation) DLQI score was six points (±5.42 points), which indicates that DPN has a moderate effect on QoL. Conclusion: Our study results reveal the high likelihood of a family history of DPN in subjects with the condition. Overall, most subjects reported few symptoms of DPN and their QoL was only moderately affected by DPN. Still, patients might benefit from the removal of DPN lesions.

Distinct roles of two eIF4E isoforms in the germline of Caenorhabditis elegans.

Germ cells use both positive and negative mRNA translational control to regulate gene expression that drives their differentiation into gametes. mRNA translational control is mediated by RNA-binding proteins, miRNAs and translation initiation factors. We have uncovered the discrete roles of two translation initiation factor eIF4E isoforms (IFE-1, IFE-3) that bind 7-methylguanosine (m7G) mRNA caps during Caenorhabditiselegans germline development. IFE-3 plays important roles in germline sex determination (GSD), where it promotes oocyte cell fate and is dispensable for spermatogenesis. IFE-3 is expressed throughout the germline and localizes to germ granules, but is distinct from IFE-1 and PGL-1, and facilitates oocyte growth and viability. This contrasts with the robust expression in spermatocytes of IFE-1, the isoform that resides within P granules in spermatocytes and oocytes, and promotes late spermatogenesis. Each eIF4E is localized by its cognate eIF4E-binding protein (IFE-1:PGL-1 and IFE-3:IFET-1). IFE-3 and IFET-1 regulate translation of several GSD mRNAs, but not those under control of IFE-1. Distinct mutant phenotypes, in vivo localization and differential mRNA translation suggest independent dormant and active periods for each eIF4E isoform in the germline.

A proposed mechanism for central centrifugal cicatricial alopecia.

Central centrifugal cicatricial alopecia (CCCA) has an unknown mechanism. Analyzing other scarring diseases (lichen planopilaris, fibrotic kidney disease and scleroderma) may help to clarify the mechanism of scarring in CCCA. These diseases were chosen for comparison due to either their location of disease (skin or scalp specifically), or prominence in patients of African descent. Genetics, possible triggers, an autoimmune lymphocytic response, and epithelial to mesenchymal transition are potentially involved. Possible common pathways in scarring diseases and a better understanding of the CCCA mechanism will lead to further research into the pathogenesis and potential treatments of CCCA.

Cicatricial Alopecia in Identical Twin Lumbee Native American Women.

Central centrifugal cicatricial alopecia (CCCA) has become a well-known entity occurring mainly in African-American women, but is rarely encountered in other populations. This report describes a set of identical twin Lumbee Indian women, both developing cicatricial alopecia, with one sister diagnosed with CCCA overlap with lichen planopilaris and the other with CCCA. The Lumbee Tribe is a federally recognized group of Native Americans who reside in North Carolina. Lumbee Indians have shown an increased incidence of several metabolic and neurologic diseases but cicatricial alopecia has never been an identified associated disease of the Lumbee. Thus far, no published studies have shown cicatricial alopecia as occurring in identical twins or in Native Americans. This case report discusses the issues of haircare practices and genetics in contributing to cicatricial alopecia.

Diversity in dermatology: a society devoted to skin of color.

The US Census Bureau predicts that more than half of the country's population will identify as a race other than non-Hispanic white by the year 2044. Racial disparities also exist in the physician population where black individuals and Latinos are underrepresented. The Skin of Color Society (SOCS) was established to address the need for parity among dermatology patients with skin of color. The society provides educational support on dermatologic health related to skin of color and functions through committees that represent the multifaceted aspects of the organization. This column highlights the ongoing efforts of SOCS and its impact since its inception. We also chronicle the society's approach to broadening the scope of the specialty of dermatology.