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1.
Nat Prod Res ; : 1-11, 2023 Dec 02.
Article in English | MEDLINE | ID: mdl-38041627

ABSTRACT

A highly stereoselective total synthesis of polyrhacitide A, a polyketide natural product, has been accomplished by means of Prins cyclisation. The key precursor i.e. anti-1,3-diol for polyrhacitide A has been prepared from trans-2,6-disubstituted-3,4-dihydropyrans. In this approach, Prins cyclisation has successfully been utilised twice for the construction of 1,3-diol unit of polyrhacitide A. The key steps involved in this approach are Jacobsen hydrolytic kinetic resolution, Mitsunobu inversion, Prins cyclisation and Ring-closing metathesis (RCM).

2.
Org Biomol Chem ; 21(42): 8426-8462, 2023 Nov 01.
Article in English | MEDLINE | ID: mdl-37831479

ABSTRACT

Transition metal-catalyzed C-N bond formation reactions have gained popularity as a method for selectively transforming common C-H bonds into N-functionalized molecules. This approach is particularly useful for synthesizing aminated molecules, which require aminating reagents and amidated building blocks. Over the past two decades, significant advancements have been achieved in transition-metal-catalyzed C-H functionalization, with organic azides emerging as promising amino sources and internal oxidants. This review focuses on recent developments in utilizing sulfonyl and phosphoryl azides as building blocks for directed intra- and intermolecular C-H functionalization reactions. Specifically, it discusses methods for synthesizing sulfonamidates and phosphoramidates using sulfonyl and phosphoryl azides, respectively. The article highlights the potential of C-H functionalization reactions with organic azides for efficiently and sustainably synthesizing N-functionalized molecules, providing valuable insights into the latest advancements in this field.

3.
Heliyon ; 9(9): e19506, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37809674

ABSTRACT

The coffee white stem borer, Xylotrechus quadripes Chevrolat, 1863 (Coleoptera: Cerambycidae) - here removed from the synonymy with X. javanicus (Laporte & Gory, 1841) - is the most notorious pest in Arabica coffee plantations in many southeast Asian countries. It can cause damage up to 80% in various gardens. The borer is reported on 16 different host plants other than coffee. The severity of the pest was more commonly recorded on the Arabica coffee than on other species. More pest intensity on the coffee may be due to its innate evolutionary relation compared to other host plants. Studies revealed that the borer is more specific and attracted to the volatile of coffee plants but it is still needs a strong supporting data. Some of the behavioural and ecological-adaptations of borers leads to avoid predation and chemical-pesticides reaching them. Hence, no single method gives perfect control of this pest; therefore, harmonic use of different tools such as cultural, mechanical, physical, bio-control and chemical methods are the best way to combat this pest. Though the pest is economically important, the information on chemical and ecological behaviour, host plant resistance and recent advancements in the pest management are scanty. The present article is an endeavour to shed a light on biology, behaviour, host selection and management of X. quadripes with multiple instances, that will give a new avenue for the researchers to work on the least concerned fields to develop strong management practice and alert against future pest outbreak.

4.
Org Biomol Chem ; 21(30): 6169-6173, 2023 Aug 02.
Article in English | MEDLINE | ID: mdl-37464919

ABSTRACT

Rhodium(III)-catalyzed [3 + 2]-spiroannulation of 2-aryl-1,4-benzoxazines with 4-hydroxy-2-alkynoates has been developed for the synthesis of highly rigid spirolactones in good yields with high regioselectivity. The reaction proceeds through a cascade of C-H activation followed by C-H annulation and lactonization. In this approach, two C-C and C-O bonds are formed in a single step. This is the first report on the spiroannulation of 2,3-dihydro-1,4-benzoxazines with 4-hydroxy-2-alkynoates.

5.
Carbohydr Res ; 528: 108811, 2023 Jun.
Article in English | MEDLINE | ID: mdl-37094532

ABSTRACT

A novel three-component strategy has been developed for the synthesis of iminosugars in good to excellent yields. This is the first report on the Mannich type addition of cyclic 1,3-diketones to aza-acetal derived from hydroxy-γ-lactone and arylamine to produce a novel series of aza-sugars with high selectivity.


Subject(s)
Amines , Sugars , Stereoisomerism , Ketones , Ions
6.
Org Biomol Chem ; 21(8): 1719-1724, 2023 Feb 22.
Article in English | MEDLINE | ID: mdl-36723131

ABSTRACT

An oxidative annulation of N-arylbenzimidamides with maleimides has been developed for the first time using a catalytic amount of the [Cp*RhCl2]2 complex for the synthesis of a diverse range of 1H-benzo[4,5]imidazo[2,1-a]pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione derivatives. This method is versatile and atom-economical for producing polycyclic benzo[4,5]imidazo[2,1-a]pyrrolo[3,4-c] isoquinoline-1,3(2H)-dione scaffolds in a single step.

7.
Chem Rec ; 22(8): e202200044, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35532222

ABSTRACT

The natural products having tetrahydropyran unit with multiple chiral centers serve as magnificent building blocks for various active pharmaceutical ingredients (APIs). 'Prins cyclization is one of the wonderful strategies to construct tetrahydropyran unit stereoselectively in asymmetric synthesis. In this account, we discuss our research efforts toward the synthesis of various natural products from the past two decades (2005-2020) by using Prins cyclization as a key step. Further, the synthetic utility of this reaction was investigated and well demonstrated on various molecules successfully.


Subject(s)
Biological Products , Cyclization , Molecular Structure , Stereoisomerism
8.
Org Biomol Chem ; 19(27): 6085-6091, 2021 07 21.
Article in English | MEDLINE | ID: mdl-34260671

ABSTRACT

A chiral Cu(i)-bisoxazoline complex catalyzed enantioselective electrophilic fluorination of 3-indolinone-2-carboxylates with NFSI has been accomplished to produce chiral 2-fluoro-3-indolinone-2-carboxylates in good yields with excellent enantioselectivities. This is the first report on the enantioselective fluorination of 2-substituted 3-indolinones using a chiral Cu(i)-bisoxazoline complex.

9.
Bioorg Med Chem ; 41: 116212, 2021 07 01.
Article in English | MEDLINE | ID: mdl-34000507

ABSTRACT

Respiratory infections resulting from pulmonary inflammation emerging as a leading cause of death worldwide. However, only twenty-seven new drugs were approved in the last five decades. In this review, we presented synthetic approaches for twenty-seven FDA-approved medications used to treat asthma and chronic obstructive pulmonary diseases (COPD), along with their mode of action.


Subject(s)
Adrenal Cortex Hormones/pharmacology , Adrenergic beta-2 Receptor Agonists/pharmacology , Asthma/drug therapy , Muscarinic Antagonists/pharmacology , Pulmonary Disease, Chronic Obstructive/drug therapy , Adrenal Cortex Hormones/chemistry , Adrenergic beta-2 Receptor Agonists/chemistry , Cyclic Nucleotide Phosphodiesterases, Type 4/genetics , Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism , Humans , Muscarinic Antagonists/chemistry , United States , United States Food and Drug Administration
10.
Org Biomol Chem ; 18(38): 7514-7532, 2020 10 07.
Article in English | MEDLINE | ID: mdl-32940271

ABSTRACT

Tandem Prins cyclization is a versatile method for the synthesis of fused/bridged/spirotetrahydropyran scaffolds. Therefore, it has become a powerful tool for the stereoselective synthesis of oxygen/nitrogen containing heterocycles. Indeed, previous review articles on Prins spirocyclization illustrate the synthesis of spirotetrahydropyran derivatives and the aza-Prins reaction demonstrates its application in the total synthesis of natural products. The current review is devoted specifically to highlight tandem Prins cyclizations for the construction of fused scaffolds and related frameworks with a particular emphasis on recent applications. The mechanistic aspects and the scope of the methods are briefly discussed herein.

11.
Org Biomol Chem ; 18(36): 7224, 2020 Sep 23.
Article in English | MEDLINE | ID: mdl-32926062

ABSTRACT

Correction for 'Tandem Prins cyclization for the synthesis of indole fused spiro-1,4-diazocane scaffolds' by Chandrashekhar Rapelli et al., Org. Biomol. Chem., 2020, 18, 6710-6715, DOI: 10.1039/D0OB01384F.

12.
Org Biomol Chem ; 18(34): 6710-6715, 2020 09 14.
Article in English | MEDLINE | ID: mdl-32820793

ABSTRACT

A novel strategy has been developed for the synthesis of indole fused spiro-1,4-diazocane derivatives. Using a tandem Prins cyclization, this is the first report on the synthesis of eight-membered spirodiazocane scaffolds, which are less accessible due to ring strain but more relevant to drug discovery.


Subject(s)
Indoles
13.
Org Biomol Chem ; 17(44): 9627-9630, 2019 11 28.
Article in English | MEDLINE | ID: mdl-31667479

ABSTRACT

A metal-free radical cyclization strategy has been developed for the synthesis of fused benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives from N-methacryloyl-2-arylbenzoimidazole and aryl aldehydes using 70% tert-butylhydroperoxide in water (TBHP). The reaction proceeds through a sequential acyl radical addition/cyclization strategy. This method is useful for the generation of biologically relevant tetracyclic scaffolds in a single-step process.

14.
Chem Asian J ; 14(17): 2958-2965, 2019 Sep 02.
Article in English | MEDLINE | ID: mdl-31241858

ABSTRACT

A highly enantio- and diastereoselective Mannich reaction of cyclic N-acyl ketimines generated in situ from 3-hydroxyisoindolin-1-ones with cyclic enones has been accomplished using a chiral phosphoric acid catalyst to afford the chiral isoindalinone derivatives in high yields with excellent enantioselectivities (upto 97 % ee). This is the first report on the synthesis of chiral isoindolin-1-ones bearing adjacent quaternary and tertiary stereogenic centers.

15.
Org Biomol Chem ; 16(28): 5163-5166, 2018 07 18.
Article in English | MEDLINE | ID: mdl-29964283

ABSTRACT

An intramolecular annulation strategy has been developed for the synthesis of tetrahydrobenzo[e]pyrano[4,3-c][1,2]thiazine derivatives by means of coupling of aldehydes with 2-(4-hydroxybut-1-yn-1-yl)-N-arylsulfonamides using a catalytic amount of silver hexafluoroantimonate in toluene at 80 °C. This is the first report on the synthesis of fused benzo-δ-sultam derivatives through C-N, C-O, and C-C bond formations. The reaction proceeds through a cascade of hydroamination and Prins type cyclization.

16.
RSC Adv ; 8(6): 3141, 2018 Jan 12.
Article in English | MEDLINE | ID: mdl-35543994

ABSTRACT

[This corrects the article DOI: 10.1039/C6RA05661J.].

17.
Org Biomol Chem ; 15(36): 7580-7583, 2017 Sep 20.
Article in English | MEDLINE | ID: mdl-28861572

ABSTRACT

A novel strategy has been developed for the synthesis of chromeno[3,4-b]pyrrol-4(3H)-one and substituted pyrrole derivatives through 1,5-electrocyclization of conjugated azomethine ylides. This is the first example of the preparation of highly substituted pyrrole derivatives from chromene-3-carboxaldehydes (non-enolizable aldehydes) and N-alkyl amino acids/esters. This method is simple and applicable to a diverse range of substrates.

18.
Org Lett ; 19(1): 170-173, 2017 01 06.
Article in English | MEDLINE | ID: mdl-28009174

ABSTRACT

An efficient enantioselective α-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired α-hydrazino esters are obtained in excellent yields with high enantiomeric excess leading to a quaternary stereocenter with a broad substrate scope.

19.
Org Biomol Chem ; 14(48): 11396-11401, 2016 Dec 07.
Article in English | MEDLINE | ID: mdl-27858034

ABSTRACT

A broad range of aldehydes undergo a smooth cascade cyclization with (E)-5-(3-phenylprop-2-ynylamino)pent-3-en-1-ol in the presence of BF3·OEt2 at room temperature to furnish a novel series of (octahydro-1H-pyrano[3,4-c]pyridin-5-yl)methanone derivatives in good yields and diastereoselectivities. This cascade process provides a simple and proficient alternative for the stereoselective construction of fused pyranopiperidine derivatives.

20.
Org Biomol Chem ; 14(37): 8832-8837, 2016 Sep 21.
Article in English | MEDLINE | ID: mdl-27714240

ABSTRACT

A novel bicyclization strategy has been developed for the stereoselective synthesis of bicyclic lactones, i.e. 7-aryl or alkyl-2,6-dioxabicyclo[3.3.1]nonan-3-ones through a domino cyclization of (R)-3-hydroxyhex-5-enoic acid with an aldehyde in the presence of 10 mol% trimethylsilyltriflate under mild conditions. The salient features of this methodology are high yields, excellent selectivity, low catalyst loading and faster reaction times. This method has been successfully applied to the total synthesis of pyranopyran, tetraketide and polyrhacitide A.


Subject(s)
Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis , Cyclohexanones/chemical synthesis , Disaccharides/chemical synthesis , Lactones/chemical synthesis , Pyrans/chemical synthesis , Aldehydes/chemical synthesis , Aldehydes/chemistry , Bridged Bicyclo Compounds, Heterocyclic/chemistry , Catalysis , Cyclization , Cyclohexanones/chemistry , Disaccharides/chemistry , Lactones/chemistry , Models, Molecular , Pyrans/chemistry , Stereoisomerism , Trimethylsilyl Compounds/chemical synthesis , Trimethylsilyl Compounds/chemistry
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