[Medico-social and clinico-biochemical aspects of longevity in Siberia]. / Uber medizinisch-soziale und klinisch-biochemische Aspekte der Langlebigkeit in Sibirien.

Over 90-year old inhabitants of districts of Novosibirsk were questioned in connection with sociological studies about their living habits. The authors consider the genetically determined system of monooxygenases for the elimination of foreign bodies (xenobiotics) to be important, but they are also involved in the synthesis of biologically active substances in the organism and thus by no means of minor importance to the phenomenon of longevity.

[Age-related microsomal hydroxylase activity in virtually healthy persons]. / Aktivnost' mikrosomal'nykh gidroksilaz v vozrastnom aspekte u prakticheski zdorovykh liudei.

Activity of microsomal hydroxylases was estimated by measuring the half-life of antipyrine secretion in healthy person saliva. Individual differences were found in the enzymatic activity. There main age groups exhibiting various activities of the microsomal enzymes were defined as follows: 1. 4-13 yrs -- high enzymatic activity; 2. 13-60 yrs -- stable activity; 3. older than 60 yrs -- decrease in the enzymatic activity. There were no sex variations in the microsomal enzymes activity.

[Indirect method of determining drug-metabolizing enzyme activity and its clinical application]. / Nepriamoi metod opredeleniia aktivnosti fermentov, metaboliziruiushchikh lekarstvennye veshchestva, i ego primenenie v klinike.

Activity of microsomal enzymes was studied using an indirect method for estimation of the rate of antipyrine secretion with saliva in 70 healthy persons at the age from 16 to 86 years. Distinct individual differences were observed in the activity of the enzymes: time of the antipyrine half-secretion varied from 6.4 hrs to 50.1 hrs. The time of antipyrine half-secretion was significantly higher in the older (60-86 years) than in younger persons (16-30 years), suggesting decreased activity of the microsomal enzymes in older people. The microsomal enzymes activity might be increased distinctly under effect of several drugs, especially of hypotensive drugs--reserpine and dibasole. The data obtained suggest that for effective medicinal therapy it is essential to control the initial activity of microsomal enzymes as well as its alterations in the course of medicamentous treatment; the activity of microsomal enzymes in a given person must be taken into consideration for correct individual selection of doses of the drugs.