ABSTRACT
We describe a benign diffuse neurofibroma of the pylorus, unassociated with von Recklinghausen's neurofibromatosis, which was a cause of pyloric stenosis; epigastric discomfort, vomiting, and weight loss of 60 lb were the most prominent symptoms. Partial gastrectomy resulted in a cure. The literature on nerve-sheath tumors of the stomach is reviewed.
Subject(s)
Neurofibroma/complications , Pyloric Stenosis/etiology , Pylorus , Stomach Neoplasms/complications , Aged , Humans , Male , Neurofibroma/pathology , Stomach Neoplasms/pathologySubject(s)
Adenocarcinoma/pathology , Colonic Neoplasms/pathology , Hernia, Inguinal/pathology , Aged , Aged, 80 and over , Colon/pathology , Humans , MaleABSTRACT
We report a 31-year-old man in whom initially localized lymphomatoid granulomatosis was diagnosed at left pneumonectomy. He had severe anemia which is rare and clubbing of the fingers and toes, a feature not previously described. Five months following surgery, disease spread to the right lung, and atypical lymphomatous transformation occurred in cervical and mediastinal lymph nodes, leading to a superior vena cava syndrome. Chemotherapy with cyclophosphamide and prednisone resulted in significant resolution initially, but ultimately, the patient had progressive axillary node enlargement and succumbed. Clinical and roentgenographic improvement and later deterioration following pneumonectomy and improvement with chemotherapy were mirrored by changes in degree of clubbing, leukocytosis, and elevation of erythrocyte sedimentation rate.
Subject(s)
Anemia, Hypochromic/complications , Lung Neoplasms/complications , Lymphoma/diagnosis , Lymphomatoid Granulomatosis/complications , Osteoarthropathy, Secondary Hypertrophic/complications , Toes , Adult , Humans , Lung Neoplasms/therapy , Lymphoma/therapy , Lymphomatoid Granulomatosis/diagnosis , Lymphomatoid Granulomatosis/therapy , Male , Vascular Diseases/etiology , Vena Cava, SuperiorSubject(s)
Aortic Aneurysm/diagnosis , Aortic Dissection/diagnosis , Echocardiography , Humans , Male , Middle AgedABSTRACT
Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are distinctive macroscopically, pathognomonic microscopically, and characterized by acute focal ovarian cortical necrosis with numerous cytomegalic cells and a variable but usually severe inflammatory reaction. It is suggested that reduced ovarian cortical vascular perfusion reactivates a latent infection in cortical stromal cells. This elicits inflammatory necrosis and the characteristic morphological lesions. This previously unreported lesion is not likely to have clinical importance.
