[Experience gained with the training of interns-hygienists and its use in creating the structure of an integrated licensing examination "Step 3 - Sanitary-Hygienist Work"]. / Dosvid pidhotovky likariv-interniv hihiienichnoho profiliu ta ioho vykorystannia pry stvorenni struktury intehrovanoho litsenziinoho ispytu "Krok 3--sanitarno-hihiienichna sprava."

The experience gained with the training of interns-hygienists at the National Medical University has proved its value, contributing to which fact were modern material-and-technical resources, close cooperation of chairs of hygiene with sanitary epidemiologic stations and scientific-research institutes, highly skilled scientific and teaching personnel, systematic sharing of experience gained in training of specialists with institutions of higher learning of Ukraine. However, interns, Masters, practitioners are still in great need of modern educational literature/training aids. There has not yet been developed a general concept of structure of sanitary epidemiological service of Ukraine, forms and methods of its work under present-day conditions. Publication of joint educational literature and textbooks of methodics to complete training of physicians-hygienists, Masters in hygiene and epidemiology, introduction of an integrated licensed examination "Step 3--Sanitarno-Gigiyenicheskoye Delo" (sanitation-and-hygiene-related work) will, we believe, help in solving the above problems.

[The environment and health status of Ukraine's population before and after the Chernobyl AES accident]. / Sostoianie okruzhaiushchei sredy i uroven' zdorov'ia naseleniia Ukrainy do i posle avarii na Chernobyl'skoi AES.

Qualitative and quantitative analyses of the environment and human health during 5 years before and after the Chernobyl accident (1986) provided an original scheme and methods for hygienic assessment of the negative influence of environmental pollution on health. They were tested in the Kiev Region. The accident was found to essentially complicated the environmental and sanitary situation in the region and to negatively affect human health.

[Role of trace elements in the development of chronic ischemic heart disease]. / Rol' mikroélementov v razvitii khronicheskoi ishemicheskoi bolezni serdtsa.

It was shown that determination of erythrocyte superoxide dismutase activity proves to be the adequate test of antioxidant protection under chronic coronary heart disease as well as the reliable laboratory test for the control of the effect of prophylactic ultra-violet radiation.

[Metabolism in experimental chronic ischemic heart disease]. / Osobennosti metabolizma pri khronicheskoi ischemicheskoi bolezni serdtsa v éksperimente.

An increase in frequency of heart contractions, changes in the bioelectrical heart activity and decrease of the force-pump heart function are observed in the rabbits with model chronic ischemic heart disease lipid metabolism in significantly changed the concentration of cholesterol in the right ventricle myocardium as well as the concentrations of unsaturated lipid acids in the heart tissues increase, while the content of saturated lipid acids and antioxidant activity of plasma decrease. Bioenergetic processes change as follows: succinate-dehydrogenase and alpha-keto-glutarate-dehydrogenase activity decrease, while the concentrations of glycogen, lactic and pyruvic acids and lactate dehydrogenase activity in the heart tissues increase.

[The relation between oxidative processes and the glycogen content in the heart and liver of rabbits with chronic ischemic heart disease]. / Sviaz' mezhdu okislitel'nymi protsessami i soderzhaniem glikogena v serdtse i pecheni krolikov pri khronicheskoi ishemicheskoi bolezni serdtsa.

While laboratory experimental model of coronary heart disease (according to Frol'kis et al.) is developed, activity of succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, Na+, Ka(+)- and Mg2+ ATPase decreases, but activity of lactate dehydrogenase and concentrations of lactic and pyruvic acids in the heart tissue increase. At the same time concentration of glycogene increases more than twice. As far as we can see there is an evidence of a decrease of glycogene utilization due to change in levels of regulatory processes. Despite a decrease of ATP synthesis by the inhibition of tricarboxylic acid cycle the ATP:ADP relation reduces to ATP, as emphatic inhibition of ATPase in the heart tissues takes place in development of the model of the coronary heart disease. The relation between ATP and ADP is considered as a regulator of glycogene utilization. In the liver tissue activity of succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, Na+, K(+)- and Mg2+ ATPase falls, while concentrations of lactic acid grow. No accumulation of glycogen is observed. It is obvious that there are controversial metabolic processes. Experimental data are discussed.

[The effect of ultraviolet irradiation on the cesium-137 and strontium-90 levels in the body of laboratory animals]. / Vliianie ul'trafioletovogo oblucheniia na soderzhanie tseziia-137 i strontsiia-90 v organizme laboratornykh zhivotnykh.

A 10-day course of ultraviolet radiation (intensity: 1/8-2 biodoses daily) did not favour accumulation of cesium-137 in the body but produced some effect on the accumulation of strontium-90. In the real radiation condition in the city of Kiev the daily prophylactic 1/8 biodose may be considered as absolutely safe.

[Effect of ultraviolet irradiation on calcium, sodium and potassium levels in albino rats]. / Vliianie ul'trafioletovogo oblucheniia na soderzhanie kal'tsiia, natriia i kaliia v organizme belykh krys.

Data presented by the authors testifies to the fact that neither 2 weeks, nor one month after the 10-day course of ultraviolet irradiation (UVR) with an intensity from 1/4 up to 2 biodoses daily changes in calcium, sodium and potassium content in blood serum of laboratory animals (white rats) were detected. At the same time, 2 weeks following the cessation of UVR course a tendency towards calcium accumulation in the whole organism of laboratory animals was observed, which was most noticeable+ after daily 10-day exposure to UVR with an intensity from 1/2 up to 1 biodose. The tendency was still present one month following the termination of UVR course. The total sodium and potassium store in the whole organism of laboratory animals did not practically change either immediately, or 2 weeks, or 1 month after the termination of 10-day UVR course with the intensity from 1/4 to 2 biodoses daily.

[The biochemical role of selenium in animal orgamisms]. / Biokhimicheskaia rol' selena v organizme zhivotnykh.

Data on the biochemical function of selenium in animal and human organism are generalized from the view point of its participation in the active centre of glutathione peroxidase and its general anabolic effect. Now it is assumed that many chronical human diseases such as cancer, cardiovascular insufficiency, atherosclerosis, pancreas insufficiency and other may be connected with selenium deficiency in human nutrition. A problem is considered on ecological and endogenous factors controlling the availability of selenium in animals. Among them the dominant role of neurohumoral regulation is emphasized and several problem, particularly in the direction of well grounded application of its low-toxic preparations to medicine, is stressed.

[Histopathomorphologic changes in the organs and tissues of laboratory animals receiving an artificial diet with a low selenium and vitamin E content]. / Gistopatomorfologicheskie izmeneniia v organakh i tkaniakh laboratornykh zhivotnykh, poluchavshikh iskusstvennyi ratsion s nizkim soderzhaniem selena i vitamina E.

The deficiency of selenium and vitamin "E" is not infrequently noted to occur in agricultural and game-animals. Its development in humans is not ruled out. Experiments set up on mice of the CC57 lineage fed on an artificial ration with a low selenium and vitamin "E" content showed an acute selenium and vitamin "E" deficit apt to call forth profound histopathomorphological changes that become apparent following hematoxylin-eosin staining in the pancreas, liver, heart, kidneys, testes and muscular tissue. Evidence was obtained for the first time that an acute selenium and vitamin "E" deficiency leads up to a drastic fall in the content of zinc, determined by the sulfargentic method, as well as in the insular cells of the pancreas, in the renal parenchyma and in the cells of the spermatogenic epithelium of the testes.