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1.
[Enteral nutrition in critically ill children: identification of the major pathological syndrome].
Shen', N P; Saifitdinov, Iu Kh; Suchkov, D V; Zhitinkina, N V.
Anesteziol Reanimatol ; (1): 63-6, 2009.
Article in Russian | MEDLINE | ID: mdl-19350726

Subject(s)
Critical Illness/therapy , Enteral Nutrition/methods , Gastrointestinal Agents/therapeutic use , Intestinal Diseases/prevention & control , Adolescent , Child , Child, Preschool , Gastrointestinal Agents/administration & dosage , Gastrointestinal Motility/drug effects , Gastrointestinal Motility/physiology , Hemodynamics/drug effects , Hemodynamics/physiology , Humans , Intestinal Diseases/etiology , Intestinal Diseases/immunology , Intestinal Diseases/metabolism , Intestinal Diseases/physiopathology , Oxidative Stress/drug effects , Syndrome
2.
Obtaining and characterization of EF-hand mutants of recoverin.
Alekseev, A M; Shulga-Morskoy, S V; Zinchenko, D V; Shulga-Morskaya, S A; Suchkov, D V; Vaganova, S A; Senin, I I; Zargarov, A A; Lipkin, V M; Akhtar, M; Philippov, P P.
FEBS Lett ; 440(1-2): 116-8, 1998 Nov 27.
Article in English | MEDLINE | ID: mdl-9862438

ABSTRACT

Several EF-hand recoverin mutants were obtained and their abilities to bind to photoreceptor membranes and to inhibit rhodopsin kinase were determined. The mutants with the 'spoiled' 2nd, 3rd or (2nd+3rd) EF-hand structures did not act upon the kinase activity in the microM range of Ca2+ concentrations. Mutations of the 4th EF hand, which 'repaired' its Ca2+-binding activity, resulted in recoverin with three 'working' Ca2+-binding sites. The latter mutant inhibited rhodopsin kinase even more effectively than the wild-type recoverin, containing two working Ca2+-binding structures.


Subject(s)
Calcium-Binding Proteins/genetics , Calcium-Binding Proteins/metabolism , Eye Proteins , Lipoproteins , Mutation , Nerve Tissue Proteins , Protein Kinase Inhibitors , Protein Kinases , Rod Cell Outer Segment/metabolism , Animals , Binding Sites , Calcium/metabolism , Calcium-Binding Proteins/chemistry , Cattle , G-Protein-Coupled Receptor Kinase 1 , Hippocalcin , Mutagenesis, Site-Directed , Phenotype , Phosphorylation , Protein Structure, Secondary , Recoverin , Retina
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