ABSTRACT
Children are uniquely vulnerable to environmental health risks associated with industrial contamination, and early childcare and education (ECE) facilities are important sites for potential exposure to environmental contaminants. Emerging research on historic urban industry has additionally demonstrated that urban environmental risk accumulates historically and spatially across urban landscapes. Accordingly, this study pairs cross-sectional data on licensed childcare facilities with longitudinal manufacturing site data in Providence, Rhode Island. We use these data to investigate the proximity of ECE facilities to active and relic manufacturing sites, controlling for a range of organizational- and tract-level characteristics. Results show that type of childcare facility (center-based vs. in-home) and language of instruction (Spanish vs. English) are important predictors of children's proximity to industrial lands, past and present. These findings indicate that Spanish-speaking children in Providence may experience a "double jeopardy" in the form of disproportionate legacy environmental hazards at ECE as well as at home-suggesting that the historical nature of urban industrial land use is an important mechanism of environmental inequality for young children.
ABSTRACT
Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct the release of molecules away from the implantation site. Though suitable for a range of applications, these catheters are designed for drug delivery to transplanted adipose tissue in patients having undergone a fat grafting procedure. A common complication for fat grafts is the rapid reabsorption of large volume adipose transplants. In order to prolong volume retention, biodegradable catheters can be embedded into transplanted tissue to deliver nutrients, growth factors or therapeutics to improve adipocyte viability, proliferation, and ultimately extend volume retention. Two fabrication methods are developed: a silk gel-spinning technique, which uses a novel flash-freezing step to induce high porosity throughout the bulk of the tube, and a dip-coating process using silk protein solutions doped with a water soluble porogen. Increased porosity aids in the diffusion of drug through the silk tube in a controllable way. Additionally, we interface the porous tubes with ALZET osmotic pumps for implantation into a subcutaneous nude mouse model. The work described herein will discuss the processing parameters as well as the interfacing between pump and cargo therapeutic and the resulting release profiles. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 501-510, 2019.
