ABSTRACT
Two cases of acidophil adenoma of the pituitary causing sudden blindness from pituitary apoplexy are presented. The tumours had been clinically silent, without producing any symptoms of endocrine dysfunction. Radiological evidence was very conclusive. Transfrontal craniotomy with decompression resulted in quick and dramatic visual improvement. The interesting syndrome of clinical manifestations is discussed.
Subject(s)
Blindness/etiology , Pituitary Apoplexy/complications , Adenoma, Acidophil/complications , Adenoma, Acidophil/diagnosis , Adenoma, Acidophil/pathology , Adenoma, Acidophil/surgery , Adult , Fundus Oculi , Humans , Male , Middle Aged , Pituitary Apoplexy/diagnosis , Pituitary Gland/diagnostic imaging , Pituitary Gland/pathology , Pituitary Gland/surgery , Pituitary Neoplasms/complications , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/pathology , Pituitary Neoplasms/surgery , Tomography, X-Ray ComputedABSTRACT
Presented is a rare case of cavernous sinus thrombosis of nasal septic origin leading to ophthalmoplegia and blindness of the ipsilateral eye and contralateral visual field involvement. An attempt is made to correlate the aetiopathology with the clinical features.
Subject(s)
Blindness/etiology , Cavernous Sinus , Ophthalmoplegia/etiology , Optic Atrophy/etiology , Sinus Thrombosis, Intracranial/complications , Adult , Exophthalmos/etiology , Humans , Male , Visual FieldsABSTRACT
Wheat cultivated in seleniferous soils of some districts of Punjab/India contained on an average 12.5 ppm selenium. These grains when fed for 4 weeks to laboratory rats, were found to cause reduction of testicular weights and interruption of spermatogenesis. Seminiferous tubules were severely affected and contained spermatogenic cells at different stages of regression. The population of spermatids was first to be affected as they showed clumping leading to the formation of giant cells. Interstitial tissue in the testes of rats fed on seleniferous wheat grains appeared oedematous and widened than that of controls. The results, therefore, revealed that selenium toxicity, in addition to its known effects in female rats, has an adverse effect on reproduction in the male rats.
Subject(s)
Selenium/toxicity , Spermatogenesis/drug effects , Administration, Oral , Animal Feed , Animals , Body Weight/drug effects , Male , Organ Size/drug effects , Rats , Rats, Inbred Strains , Selenium/administration & dosage , Testis/drug effects , Testis/pathology , Triticum/analysisSubject(s)
Carboxypeptidases/analysis , Pancreas/enzymology , Phenanthrolines , Animals , Buffaloes , Carboxypeptidases ASubject(s)
Cross Reactions , Hypersensitivity, Delayed/immunology , Tuberculin Test , Tuberculosis/immunology , Animals , Antigens, Bacterial/immunology , Dose-Response Relationship, Immunologic , Guinea Pigs , Kinetics , Macrophage Migration-Inhibitory Factors , Mycobacterium avium/immunology , Mycobacterium tuberculosis/immunologyABSTRACT
Guinea pigs were sensitized with heat killed M. tuberculosis, M. kansasii, M. scrofulaceum, and M. avium-intracellulare. Purified Protein Derivatives (PPDs) prepared from each of these organisms were tested for delayed type hypersensitivity by lymphocyte transformation, macrophage migration, and mantoux type skin sensitivity tests. The homologous reactions were consistently more intense than heterologous reactions in all three procedures. The skin test procedure was more sensitive than either in vitro method. Positive skin test reactions were elicited with 2 times and 50 times less antigen than, respectively, the lymphocyte transformation and the macrophage migration tests.
