ABSTRACT
PURPOSE: To describe Sporothrix schenckii conjunctivitis in 2 owners of cats with sporotrichosis. METHODS: Small case series and literature review. RESULTS: Two women had been caring for their pet cats with sporotrichosis for 2 months but did not recall any traumatic injury such as scratches or bites. Each presented a conjunctival granulomatous lesion measuring 4 to 5 mm accompanied by local hyperemia, secretion, and edema, in addition to painful facial subcutaneous nodes and regional lymph node enlargement. Pyogenic material was collected from the conjunctival sac and from cutaneous lesions on the cats. In both the patients and their respective cats, fungal colonies were isolated and identified as S. schenckii. Treatment with oral itraconazole 100 mg/d for 3 months resulted in complete healing of lesions in both patients. Patients remained clinically cured 15 months after end of treatment. CONCLUSION: Sporotrichosis is presently occurring as an emerging zoonosis in Rio de Janeiro, and some unusual clinical forms have been diagnosed in humans. The cases reported here suggest atraumatic exposure to cats infected by S. schenckii.
Subject(s)
Antifungal Agents/therapeutic use , Conjunctival Diseases/drug therapy , Itraconazole/therapeutic use , Sporotrichosis/drug therapy , Adult , Animals , Brazil/epidemiology , Cat Diseases , Cats , Conjunctival Diseases/pathology , Disease Outbreaks , Female , Humans , Middle Aged , Sporotrichosis/epidemiology , Sporotrichosis/pathology , Zoonoses/epidemiologyABSTRACT
A toxoplasmose ocular é a causa mais frequente de uveíte em nosso meio. Realizamos estudo de caráter prospectivo no Hospital Evandro Chagas, Fundaçäo Oswaldo Cruz, e avaliamos 83 pacientes com diagnóstico de uveíte posterior, dos quais 34 (40,97 por cento) apresentaram quadro clínico, laboratorial e resposta terapêutica compatíveis com toxoplasmose ocular. Verificamos uma predominância de pacientes na faixa etária de 10 a 39 anos, com total de 27 (85,29 por cento) e do sexo feminino, com 21 (61,77 por cento). A lesäo se localizou na regiäo periférica da retina em 23 (67,65 por cento), na regiäo periférica e macular em 8 (23,53 por cento) e na regiäo macular em 3 (8,82 por cento) e apresentou contiguidade com lesäo cicatrizada em 18 (52,95 por cento) dos pacientes. Em 31 pacientes com toxoplasmose ocular, a imunofluorescência indireta apresentou resultados positivos para IgG em títulos compatíveis com infecçäo crônica. Em três, observamos toxoplasmose aguda, associada à lesäo ocular apresentando títulos de IgG e IgM positivos. Cinco pacientes apresentaram recorrência da lesäo no período de 3 anos de observaçäo