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Farmakol Toksikol ; 44(1): 109-15, 1981.
Article in Russian | MEDLINE | ID: mdl-6266869

ABSTRACT

Experiments on an isolated ileum of the rat with experimental hyperlipidemia have shown the decreased acetylation rate of sulfalen, sulfamonomethoxin and sulfapyridazine. The absorption rate of the free forms of sulfanilamides was increased (significantly for sulfalen and sulfapyridazine). Isadrin (1 . 10(-8) M) and cAMP (1 . 10(-5) M) introduced into the liquid exposed to the mucosa of the rat ileum raised the acetylation rate of sulfamonomethoxin by the ileic wall while anaprilin (1 . 10(-6) M) led to the reduction of both absorption and acetylation of this sulfanilamide. Addition of cAMP to the incubation mixture of mitochondria and microsomes increased the acetylation rate of sulfamonomethoxin.


Subject(s)
Hyperlipidemias/metabolism , Sulfanilamides/metabolism , Acetylation , Animals , Biotransformation , Cyclic AMP/pharmacology , Intestinal Absorption , Isoproterenol/pharmacology , Liver/metabolism , Propranolol/pharmacology , Rats , Sulfalene/metabolism , Sulfamethoxypyridazine/metabolism , Sulfamonomethoxine/metabolism
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