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Bioorg Med Chem
; 26(8): 1832-1847, 2018 05 01.
Article
in English
| MEDLINE
| ID: mdl-29486951
ABSTRACT
The design and synthesis of a novel class of 7-azaspiro[3.5]nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R2) and the left aryl group (R3) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose lowering effect in diabetic rats.