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1.
J Biosci Bioeng ; 99(4): 361-5, 2005 Apr.
Article in English | MEDLINE | ID: mdl-16233802

ABSTRACT

2-O-(beta-D-Glucopyranosyl)ascorbic acid (AA 2 beta G) isolated from a popular traditional Chinese food (Lycium fruit) was synthesized using cellulase derived from Trichoderma sp. with cellobiose as a glucose donor. 6-O-(beta-D-Glucopyranosyl)ascorbic acid as well as AA 2 beta G was also synthesized in this reaction. The vitamin C activity of AA 2 beta G was also evaluated using inherently scorbutic (osteogenic disorder Shionogi [ODS]) rats. The rats were fed vitamin C-deficient food and water containing AA 2 beta G for 21. AA 2 beta G supported their growth and the level of vitamin C in tissues was moderately maintained. The vitamin C level in some tissues depended on the hydrolytic activity of AA 2 beta G (beta-glucosidase activity) although the correlation was not statistically significant (P=0.08). The results indicate that AA 2 beta G has pro-vitamin C activity.


Subject(s)
Ascorbic Acid/analogs & derivatives , Body Weight/drug effects , Cellobiose/chemistry , Cellulase/chemistry , Trichoderma/enzymology , Administration, Oral , Animals , Ascorbic Acid/administration & dosage , Ascorbic Acid/chemistry , Dietary Supplements , Enzyme Activation , Male , Rats
2.
J Agric Food Chem ; 52(7): 2092-6, 2004 Apr 07.
Article in English | MEDLINE | ID: mdl-15053557

ABSTRACT

A novel stable precursor of ascorbic acid (vitamin C), 2-O-(beta-D-glucopyranosyl)ascorbic acid, was isolated from both the ripe fresh fruit and dried fruit of Lycium barbarum L., a plant of the Solanaceae family. The chemical structure was inferred by instrumental analyses and confirmed by chemical synthesis. The dried fruit of Lycium barbarum L. contained ca. 0.5% of it, which is comparable to the ascorbic acid content of fresh lemons. It increased the blood ascorbic acid by oral administration to rats, and it was also detected in blood from the portal vein.


Subject(s)
Ascorbic Acid/isolation & purification , Fruit/chemistry , Lycium/chemistry , Animals , Ascorbic Acid/analogs & derivatives , Ascorbic Acid/blood , Ascorbic Acid/pharmacokinetics , Chromatography, High Pressure Liquid , Intestinal Absorption , Molecular Structure , Rats
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