[Chemiluminescence of erythrocytes of various age groups in patients with diabetes mellitus]. / Khemiliuminestsentsiia raznovozrastnykh grupp éritrotsitov u bol'nykh sakharnym diabetom.

Hydrogen peroxide-induced chemiluminescence of red cells of various age groups in diabetics was under study. A clinical, laboratory, and instrumental examination of 15 patients with diabetes mellitus was carried out. Red cell fraction chemiluminescence was examined in quantum metric equipment with FEU-39A and FEU-140 radiation detectors sensitive to the visible and UV regions. Intensive fluorescence of the third and, in some cases, of the fourth red cell fractions was observed in the diabetics, in contrast to the reference group of normal subjects (more than 3-fold higher in the patients). A high level of peroxide chemiluminescence observed at the end of examinations of the third and fourth fractions of the diabetics' red cells is an evidence of a high concentration of lipid peroxidation products in the diabetics, increased vs. the norm. Diabetes mellitus involves activation of the red cell fraction free-radical processes, leading to a preterm destruction of functionally active red cells first of all.

[Lipid peroxidation in patients with diabetes mellitus]. / Perekisnoe okislenie lipidov u bol'nykh sakharnym diabetom.

The activity of free radical oxidation in patients with diabetes mellitus was investigated with respect to a type of diabetes using chemiluminescence. Clinical, laboratory and instrumental investigation of 80 patients with diabetes mellitus was conducted. The level of free radical oxidation in the patients changed as compared to that in the controls. Direct correlation between an increase in a degree of severity of disease and a rise of the level of chemiluminescence was discovered. Changes of lipid peroxidation in patients with diabetes mellitus permitted sound recommendation of drugs with antioxidant and membrane-stabilizing properties.