ABSTRACT
UNLABELLED: The authors studied the levels of large- and medium molecular circulating immune complexes (CIC) and immunoglobulins of main classes (Ig) in 17 patients with systemic lupus erythematosus (SLE) and 47 patients with rheumatoid arthritis (RA). RESULTS: low molecular CIC increased in 35.2% of patients with SLE and in 42.5% with RA; patients with SLE showed a significant reduction of IgA in 80.4%. The IgA/IgM ratio was significantly reduced in SLE due to the above finding. The IgA level remained unchanged in RA.
Subject(s)
Antigen-Antibody Complex/blood , Arthritis, Rheumatoid/immunology , Immunoglobulins/analysis , Lupus Erythematosus, Systemic/immunology , Adolescent , Adult , Aged , Chronic Disease , Humans , Middle Aged , Molecular WeightSubject(s)
Biocompatible Materials/pharmacology , Carbon/pharmacology , Adsorption , Animals , Biophysical Phenomena , Biophysics , Biopolymers , Hemoperfusion , Humans , Immunosorbent Techniques , RabbitsABSTRACT
The cyanogen bromide cleavage of "acetic" polyhedral protein from nuclear polyhedrosis virus of B. mori was performed. Two peptides BrCN-II and BrCN-II' which consist of 29 and 34 amino acid residue were isolated from a mixture of cyanogen bromide fragments. The amino acid composition and N-terminal amino acids were established. The tryptic proteolysis of these fragments was conducted and the tryptic peptides were separated. The amino acid composition of tryptic peptides was determined. The data obtained make it possible to consider these fragments to be internal areas of polypeptide chain of the protein under investigation.