Subject(s)
Whooping Cough/epidemiology , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Humans , Infant , Middle Aged , Moscow , Severity of Illness Index , Whooping Cough/diagnosisABSTRACT
Epidemiological surveys with the use of the clinical and bacteriological methods of examination were carried out in 107 foci of pertussis in families (283 adults), 25 foci in children's institutions (103 employees) and 1 focus in a surgical department for infants (29 adults). The infection was shown to be widely spread among adults at present: 23.7% in the surveyed families, 10% in children's institutions and 6.9% in the surgical department for infants. In the familiies, 26.2% of the adults were the first to fall ill with pertussis. no essential differences in the terms of the release of the infective agent, as well as in the course of the disease, in adults and in vaccinated children were found. Antiepidemic measures in respect to adult pertussis patients is proposed.
Subject(s)
Whooping Cough/epidemiology , Adult , Child , Disease Reservoirs , Humans , USSR , Whooping Cough/genetics , Whooping Cough/transmissionSubject(s)
Respiratory Tract Infections/etiology , Salmonella Infections/complications , Acute Disease , Child, Preschool , Humans , Infant , Respiratory Tract Infections/diagnosis , Respiratory Tract Infections/microbiology , Salmonella Infections/diagnosis , Salmonella Infections/microbiology , Syndrome , Virus Diseases/diagnosis , Virus Diseases/etiology , Virus Diseases/microbiologySubject(s)
Whooping Cough/diagnosis , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Time Factors , Whooping Cough/physiopathology , Whooping Cough/transmissionABSTRACT
Live dysentery Sonne vaccine from a spontaneous mutant proved to be practically areactogenic and specifically harmless in oral immunization of children aged from 7 to 13 years, in doses of from 3 to 25 milliard live microbial cells and in single and triple immunization schemes. Weak reactions of the gastro-intestinal tract were noted with the same frequency (1.7%) in children immunized with the vaccine and in children given placebo (2.2%). There proved to be a significant increase in the serum of the immunized persons of the level of specific hemagglutinins, and also of the IgA-and IgM-titers in 82% of the persons vaccinated; they persisted at a high level for 2 months. The appearance of IgA-antibodies in high titres in the persons vaccinated orally pointed to a marked local and general immunological activity of the live dysentery Sonne vaccine from the spontaneous mutant processing the capacity to survive in the intestine of children for a long time.
