Dental robotics: a groundbreaking technology with disruptive potential - review article.

Dental Robotics represent a groundbreaking technological frontier with the potential to disrupt traditional paradigms in oral healthcare. This abstract explores the transformative impact of robotic applications in dentistry, focussing on precision, reproducibility, and reliability. A comprehensive search was conducted on the PubMed database, Dental and Oral Science, and CINAHL to identify pertinent studies exploring the implications of robotics in dentistry. Studies incorporated in this analysis highlighted the significance of broadening the research scope beyond implantology. This review underscores the importance of integrating robotic dentistry into educational frameworks and advancing technological preparedness. As we navigate these challenges, the abstract underscores the pivotal role of robotic dentistry in shaping the future of oral healthcare. Robotic dentistry promises transformative advancements in oral healthcare with precision and reliability. Challenges like limited system availability and expertise highlight the need for increased dentist-engineer collaboration. Diversifying research, emphasizing non-invasive technologies, and integrating robotic dentistry into education are crucial for wider acceptance. Public awareness and regulatory clarity are pivotal for seamless integration, unlocking the vast potential of robotic technologies in the future of dental care.

The application of virtual reality and augmented reality in dentistry - a literature review.

In recent times, dentistry has seen significant technological advancements that have transformed various specialized areas within the field. Developed into applications for mobile devices, augmented reality (AR) seamlessly merges digital components with the physical world, enhancing both realms while maintaining their individual separateness. On the other hand, virtual reality (VR) relies on advanced, tailored software to visualize a digital 3D environment stimulating the operator's senses through computer generated sensations and feedback. The current advances use the application of VR, haptic simulators, the use of an AI algorithm and many more that provides new opportunities for smart learning and enhance the teaching environment. As this technology continues to evolve, it is poised to become even more remarkable, enabling specialists to potentially visualize both soft and hard tissues within the patient's body for effective treatment planning. This literature aims to present the newest advancements and ongoing development of AR and VR in dentistry and medicine. It highlights their diverse applications while identifying areas needing further research for effective integration into clinical practice.

Exploring the knowledge and awareness on applications of virtual reality and augmented reality technology among dental healthcare professionals - a crosssectional survey.

OBJECTIVE: To assess the knowledge and awareness of Virtual Reality (VR) and Augmented Reality (AR) technology in dentistry. METHODS: A questionnaire survey-based study was conducted using Google forms on a sample of 273 dental healthcare professionals (DHCP) from October- November 2023, after obtaining ethical approval. A validated questionnaire, divided into three sections, was used to assess the knowledge and awareness of dental healthcare professionals on virtual and augmented reality. Section A was about demographic statistics, section B assessed knowledge and awareness regarding VR and AR and section C consisted of future acceptability of VR and AR among DHCP. The frequency of each question was reported in percentages. To assess the difference of knowledge and awareness of AR and VR among different specialties of DHCP, one-way ANOVA test was applied and in case of significant results pairwise comparison was performed by post-hoc Tukey test. RESULTS: There was a statistically significant difference of knowledge (1.40 ± 0.49) among different dental healthcare professionals. On pairwise comparison, a statistically significant difference (p = ˂0.05) of knowledge and awareness of AR and VR was found among dental specialist and other dental health professionals. CONCLUSIONS: A concerning lack of knowledge and awareness among dental healthcare professionals regarding AR and VR technology in dentistry was found. Interestingly, within the spectrum of specialties, dental specialists demonstrated a comparatively higher awareness than their counterparts in other specialties. Addressing barriers, notably a lack of knowledge, is crucial for successful technology adoption in dental education and practice.

Comparison of mesiodistal root angulation of teeth by conventional panoramic and cone beam computed tomography images - A cross-sectional study.

INTRODUCTION: Accurate bracket positioning is required for proper root parallelism and for stable orthodontic treatment outcomes. This study aimed to determine the difference in mesiodistal root angulation of teeth measured on three radiographic images. MATERIAL AND METHODS: A cross-sectional study was conducted using orthopantomogram (OPG), panoramic images of cone beam computed tomography (Pan-CBCT) and cone beam computed tomography (CBCT). An occlusal plane was constructed in OPG and Pan-CBCT for angular measurements. The axial and sagittal views were used for assessing the mesiodistal root angulation on CBCT. Mesiodistal root angulation differences among three radiographs were assessed using the Kruskal-Wallis test. Mann-Whitney U test was applied for pairwise comparison and multinomial logistic regression was used to determine the association of sexual dimorphism with the direction of root angulation. RESULTS: On comparing the mesiodistal root angulation in degrees (DE) among all three groups, upper right (UR2) and left lateral incisors (UL2) were found to be statistically significant with P=0.033 and P=0.050 respectively. On pair-wise comparison, we found a statistically significant difference for upper right lateral incisor (UR2) between OPG and Pan-CBCT (P=0.045). Upper left lateral (UL2) (P=0.024) was significant in OPG and Pan-CBCT while upper left first molar (UL6) (P=0.043) in OPG and CBCT group. On comparing the sexual dimorphism in the direction of root angulation, females showed a greater tendency of mesial root angulation (5.62) times for upper right second premolar (UR5) as compared to males. CONCLUSIONS: There were no significant difference in mesiodistal root angulation between panoramic CBCT and CBCT images. The angulation of the upper lateral incisors was found to be significant between OPG and panoramic CBCT images, whereas the angulation of the upper right lateral incisors and left first molars was significant between OPG and CBCT images. In terms on sexual dimorphism, females showed greater mesial angulation of teeth than males.

Knowledge and awareness of dental stem cells among dental healthcare professionals - a cross-sectional study.

Objectives: To assess knowledge and awareness of dental healthcare professionals on dental stem cells. METHODS: A questionnaire survey-based study was conducted using Google forms on a sample of 69 dental healthcare professionals (DHCP) from September - October 2022, after obtaining ethical approval. A validated questionnaire was used to assess the knowledge and awareness of dental healthcare professionals on stem cells, which was then divided into three sections. The section A was about demographic statistics, section B assessed knowledge and awareness regarding dental stem cells and section C consisted of 5 score VAS scale to assess the acceptability of future research and increase implication of dental stem cells (DSC) among DHCP. The frequency of each question was reported in percentages. To assess the difference of knowledge and awareness of DSC among different specialties of DHCP, one-way ANOVA test was applied and incase of significant results pairwise comparison was performed by post-hoc Tukey test. RESULTS: Mean scores of knowledge and awareness of DSC among female DHCP were 54.26 ± 11.73 and males were 53.50 ±8.19. There was a statistically significant difference of knowledge (p= 0.02) among different dental healthcare professionals. On pairwise comparison by post-hoc Tukey HSD we found statistically significant difference (p = 0.03) of knowledge and awareness of dental stem cells among general dentists and operative dentistry specialists. CONCLUSIONS: We found poor knowledge and awareness of dental healthcare professionals regarding dental stem cells. However, operative and endodontic specialty had more awareness on dental stem cells as compared to any other specialty. There was positive approach for further future researches on stem cells.

Diagnostic and prognostic role of cancer stem cell biomarkers in oral squamous cell carcinoma; A Systematic Review.

Objectives: To evaluate the role of cancer stem cell biomarkers in diagnosis and prognosis of OSCC patients. METHODS: The search strategy was entered into PubMed NLM, EBSCO CINAHL, EBSCO Dentistry & Oral Sciences Source, Wiley Cochrane Library, and Scopus. The full text eligible studies (n=7) were assessed for their quality using the JBI Critical Appraisal Checklist to evaluates the methodological quality of the studies based on possibility of bias in its design, conduct, and analysis. Selected studies were further analysed based on different parameters such as publication year, sample size, and outcomes. RESULTS: A total of 432 studies were identified through the search strategy. A total of 306 records were removed before screening either because of duplication or marked ineligible by the automation tools. The screened records were 126 out of which 104 were removed as they were not conducted on OSCC. Twenty-two reports were sought for retrieval, however, we could not find the full text of 3 studies and12 studies were excluded because the biomarkers were not associated with cancer stem cells. The most common cancer stem cell biomarkers associated with OSCC were MCT1,VEGF-A, GD15, HIF1 α, Ki67, Hsp 70, Cyclin D1, and CD44. CONCLUSIONS: Various stem cell biomarkers have been found to have diagnostic and prognostic role in oral squamous cell carcinoma such as Cyclin D1, VEGF-A, GD15, and CD44. They can be used to predict the overall survival rate, local progression-free survival rate, and distant metastasis-free survival rate in Head and Neck cancer patients.

Compliance to donning and doffing of personal protective equipment among dental healthcare practitioners during the coronavirus pandemic: a quality improvement plan, do, study and act (PDSA) Initiative.

INTRODUCTION: With the emergence of SARS-Cov-2, the Centers for Disease Control and Prevention (CDC) defined mandatory guidelines for donning and doffing personal protective equipment (PPE) among dental healthcare professionals. The study's objective was to improve the compliance of the donning and doffing protocols for PPE among dental practitioners by the Plan, Do, Study, and Act (PDSA) cycle. MATERIALS AND METHODS: A quasi-experimental study was conducted on a sample of dental healthcare professionals using the non-probability purposive technique. In the first planning stage, compliance with CDC-approved donning and doffing was assessed on the clinical premises. In the second stage, an educational session was arranged with all the healthcare professionals to explain stepwise guidelines of donning and doffing to improve the quality of donning and doffing compliance. In the third stage, improvement in the quality outcome was then assessed after the session. Data were normally distributed. Qualitative variables for all the steps of donning and doffing are reported as frequency and percentages. Pareto charts were made to assess the non-compliance rate for donning and doffing protocols among dental healthcare professionals. RESULTS: There was an improvement of 44.55% in the hand hygiene practices before wearing the PPE after the second step of the PDSA cycle. A percentage improvement of 7.4% was recorded for removing jewellery, wearing the gown and wearing a surgical cap. No improvement was seen in securing the mask/ respirator ties, washing hands after wearing the respirator, placing the goggles or face shield practices. CONCLUSIONS: PDSA cycle improved the overall compliance to PPE donning and doffing practices. Most of the protocols were followed by the dental healthcare professionals; however, some of them remained the same or worsened due to ease in SARS-CoV 2 restrictions.

Analysis of facial proportions in skeletal Class II subjects treated with Clark's twin block appliance, followed by nonextraction fixed mechanotherapy: A retrospective longitudinal study.

INTRODUCTION: This study aimed to determine the influence of Clark's twin block (CTB) appliance therapy on achieving golden proportion in post-treatment facial profiles in skeletal Class II patients. METHODS: A retrospective longitudinal study was conducted on a sample of 44 skeletal Class II subjects treated with CTB, followed by nonextraction mechanotherapy. Ricketts' 13 dentoskeletal ratios were measured on pre- and post-treatment lateral cephalograms. Paired Student's t test was used to analyze the existence of golden proportion in the values of the pre- and post-treatment ratios. The influence of pretreatment variables was tested on post-treatment ratio 4 using simple and multiple linear regression analyses. RESULTS: A statistically significant difference in pre- and post-treatment values was found for ratios 4 (P = 0.02), 9 (P = 0.04), 10 (P < 0.001), and 13 (P = 0.01). Ratios 4, 9, and 13 moved closer to the golden proportion, whereas ratio 10 moved away from the golden proportion after CTB therapy. Simple linear regression analysis showed a statistically significant association of post-treatment ratio 4 with pretreatment ratios 1, 4, 8, 9, and 12. Multiple linear regression analysis showed a statistically significant association of post-treatment ratio 4 with pretreatment ratios 4 and 12. CONCLUSIONS: Treatment with CTB appliance may well move various facial ratios in individual patients toward the published Ricketts ideals. Ricketts' published golden proportion may be used as one guide when planning for attempted dentofacial change in individual patients.

A comparison of three different modalities in improving oral hygiene in adult orthodontic patients - An open label randomized controlled trial.

INTRODUCTION: The objective of the study was to compare outcomes in terms of Bleeding index (BI), Gingival Index (GI) and Orthodontic Plaque Index (OPI) with videographic and plaque disclosing tablets (PDT) versus verbal instructions in adult orthodontic patients undergoing fixed appliance treatment (FAT). MATERIALS AND METHODS: Adult orthodontic patients were recruited form outpatient orthodontic clinic who fulfilled the inclusion criteria and were randomly allocated to three groups i.e., video, PDT AND VERBAL GROUPS: Subjects who had gingivitis as assessed by the Bleeding Index (BI), Gingival Index (GI) and Orthodontic Plaque Index (OPI) were recruited. Pre- and post-interventional measurements were taken at two intervals only for BI, GI and OPI. The primary outcome was to evaluate mean change in the BI, GI and OPI in the three study groups after six weeks. A computer-generated randomization list was used to allocate subjects to one of the three study groups using a random permuted block sampling of 6 and 9 to randomize the samples. RESULTS: A total of 99 subjects were assessed for eligibility out of which 96 participants were randomized as three of the participants declined to be part of this trial. The mean change in the oral hygiene indices score were assessed and we found no statistically significant difference among the three interventional groups. Pre- and postinterventional results showed statistically significant improvement in the oral hygiene indices for video and PDT group. No statistically significant difference for age, gender and education level on oral hygiene indices. Simple linear regression showed that video group produced significantly higher mean OPI change as compared to other groups. CONCLUSIONS: Visual aids performed better than verbal instructions. Gender, age, and education level did not have a statistically significant impact on oral hygiene indices.

Comparison of bracket bond failure with the aerosol-generating and novel non-aerosol-generating bonding techniques during the SARS-CoV-2 pandemic among orthodontic patients: A retrospective cohort study.

BACKGROUND: As per the Centers for Disease Control and Prevention (CDC) guidelines, dentists must avoid the aerosol-generating procedures during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. OBJECTIVES: This study aimed to compare the rate of bracket bond failure with the aerosol-generating and non-aerosol generating bonding techniques. MATERIAL AND METHODS: A retrospective cohort study was conducted during the SARS-CoV-2 pandemic on a sample of 44 patients (880 teeth), equally divided into 2 groups: the conventional aerosol-generating bonding technique (ABT); and the novel non-aerosol-generating bonding technique (NABT). The rate of bracket survival and total number of bracket breakages in the 2 groups were assessed by means of the survival regression analysis. The influence of pre-treatment factors, such as the sagittal jaw relationship (ANB), the Frankfort-mandibular plane angle (FMA), overjet, overbite, and upper and lower crowding, on the rate of bracket survival was also evaluated. RESULTS: There was a statistically significant difference between ABT and NABT in terms of bracket survival. The mean bracket survival with ABT was 176.21 ±77.89 days and with NABT it was 162.53 ±83.34 days. The novel technique showed a hazard ratio of bracket survival of 2.99 as compared to the conventional method. There was a statistically significant influence of overjet on the rate of bracket survival (p = 0.010). The posterior segment had a higher rate of bracket failure as compared to the anterior segment in NABT, which was statistically significant (p < 0.001). However, this difference was statistically non-significant in the case of ABT. CONCLUSIONS: There was an increased rate of bracket failure with NABT as compared to ABT. The rate of bracket breakages in the anterior quadrants was comparable for both bonding techniques.

Artificial intelligence in dentistry, orthodontics and Orthognathic surgery: A literature review.

Artificial intelligence is the ability of machines to work like humans. The concept initially began with the advent of mathematical models which gave calculated outputs based on inputs fed into the system. This was later modified with the introduction of various algorithms which can either give output based on overall data analysis or by selection of information within previous data. It is steadily becoming a favoured mode of treatment due to its efficiency and ability to manage complex conditions in all specialities. In dentistry, artificial intelligence has also popularised over the past few decades. They have been found useful for diagnosis in restorative dentistry, oral pathology and oral surgery. In orthodontics, they have been utilised for diagnosis, assessment of treatment needs, cephalometrics, treatment planning and orthognathic surgeries etc. The current literature review was planned to highlight the uses of artificial intelligence in dentistry, specifically in orthodontics and orthognathic surgery.

Acceptance of SARS-CoV-2 vaccination and the associated factors among dental health care professionals: A cross-sectional survey.

BACKGROUND: One of the greatest inventions of the 21st century is the development of vaccines against the life-threatening pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whenever a new medication or treatment modality is introduced globally, it is accompanied by anxiety in the general public and among health care professionals. OBJECTIVES: The aim of the study was to explore factors that may influence the acceptance of COVID-19 vaccination among dental health care professionals, as they are the first subgroup in the population to receive the vaccine. MATERIAL AND METHODS: A survey-based cross-sectional study was conducted on 164 health care professionals (general dentists, dental specialists with 2 years of experience after graduation and dental assistants). Data was collected by sending a URL link to the hardand soft-copy questionnaire on Google Forms through all social media platforms. The questionnaire had 2 sections - the 1st part concerned the demographic details and the 2nd part was designed to assess the acceptance of SARS-CoV-2 vaccination among dental health care professionals and the related factors. The normality of the data was assessed with the Shapiro-Wilk test. The Cox regression algorithm was applied to evaluate the factors associated with the acceptance of SARS-CoV-2 vaccination. RESULTS: Out of 164 participants, 85.37% showed a positive attitude toward vaccination and only 7.32% of dental health care professionals were not willing to get vaccinated; out of them, 5 were males and 7 were females. Those who refused to get vaccinated included 3.6% of general dentists, 21.1% of dental specialists and 11.7% of dental assistants. The complications of major concern were fever, myalgia and the lethargic condition immediately after vaccination. CONCLUSIONS: A small percentage of health care professionals declined to get vaccinated against COVID-19 and the main reason was uncertainty about the associated side effects. The respondents were mostly concerned about such side effects as fever, myalgia and the lethargic condition immediately after vaccination.

Cephalometric predictors of optimal facial soft-tissue profile in adult Asian subjects with Class II malocclusion treated via maxillary premolar extraction: A cross-sectional study.

INTRODUCTION: Class II malocclusion is most commonly treated using maxillary premolar extractions. The objective of this study was to predict cephalometric parameters associated with favorable facial soft-tissue profiles in adult Asian subjects with Class II malocclusion treated via maxillary premolar extractions. METHODS: A cross-sectional study was performed with 46 patients equally divided into favorable (FG) and unfavorable groups. The sample was divided on the basis of subjective and objective criteria. Subjectively, pretreatment and posttreatment facial silhouettes were shown to the panel of orthodontists to rate via the visual analog scale. Objectively, posttreatment soft-tissue cephalometric variables were taken. The sample receiving 60% visual analog scale and ideal posttreatment soft-tissue measurements were included in FG. Paired t test and independent t test were applied to determine the significant changes within and between both groups. To predict the cephalometric and occlusal variables associated with FG outcome, the Cox regression analysis was applied. RESULTS: On the evaluation of pretreatment cephalometric variables, the independent t test showed statistically significant differences for UI-NA (P = 0.42), Wits appraisal plane (0.010), upper lip to E-line (0.047), and interincisal angle (P = 0.049). Evaluation of the pretreatment occlusal variables the independent t test and chi-square test showed overjet (P = 0.018) and molar relationship (P = 0.045) to be statistically significant. The Cox regression analysis showed no cephalometric or occlusal variables to be statistically significant to predict the soft-tissue outcomes. A statistically significant strong correlation was also observed between the subjective and objective evaluation methods. CONCLUSIONS: Cephalometric analysis may be more valuable as a diagnostic rather than a predictive tool for favorable soft-tissue outcomes.

Predicting the sagittal skeletal pattern using dental cast and facial profile photographs in children aged 9 to 14 years.

OBJECTIVE: To quantify prediction of sagittal skeletal pattern using anteroposterior dental relationships on dental casts and facial profile photograph. Methods: The cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from December 2016 to July 2017, and comprised orthodontic patients of either gender aged 9-14 years who attended the outpatient dental clinic. The sagittal skeletal relationship assessed on cephalometric radiographs was compared with anteroposterior dental and facial measurements on their dental cast and facial profile photographs. A prediction model was developed using multiple linear regression. The applicability of the prediction model was checked on an independent sample. Data was analysed using STATA 12. RESULTS: Of the 76 patients, about two-third (n=47) were females. The overall median age was 12.3 years (inter-quartile range: 1.8), with majority (60.5%) aged 12-14 years. The proportion of Class I, II and III malocclusion was 25 (32.9%), 50 (65.8%) and 1 (1.3%) respectively. Highest percentage of variability 47.4% in ANB angle was determined by the soft tissue ANB angle. 54.9% of the variability in the ANB angle could be explained by overjet, soft tissue ANB' angle, lower lip to E-line distance, Class II incisor relationship, history of malocclusion and thumb sucking, interaction terms between Class II incisor relationship and history of malocclusion, and history of thumb sucking and soft tissue ANB' angle. CONCLUSIONS: Sagittal skeletal relationship in an individual can be predicted with moderate accuracy using the prediction equation incorporating dental and facial variables along with history of malocclusion and thumb-sucking without potentially harmful exposure to cephalometric radiographs.

Influence of incisor inclination and anterior vertical facial height on facial attractiveness in an adult Asian male.

INTRODUCTION: Balanced facial proportions and hard tissue relationships are important factors in facial attractiveness. The objective of this study was to determine the most pleasing maxillary incisal inclination (MII) on the lateral profile and the impact of various lower anterior facial height (LAFH) ratios (at rest and with a smile) on facial attractiveness. METHODS: This cross-sectional study was performed with 66 raters equally divided into 3 panels: general dentists (GD), orthodontic residents (OR), and laypersons (LP). Lateral profile view photographs of an Asian man were modified using Photoshop software (Adobe Systems, San Jose, Calif) to show altered MII and LAFH ratios at rest and when smiling. Subjective evaluations of facial attractiveness were performed by raters using a visual analog scale. Kruskal-Wallis test was used to compare esthetic scores among raters, and the Mann-Whitney U test was applied to compare ES between groups. RESULTS: Kruskal-Wallis test showed significant differences in esthetic scores among raters for -10° (P = 0.028) and -15° MII (P = 0.030). Similarly, significant differences were found in ES for 8% LAFH ratio (P = 0.022), and 4% LAFH ratio (P = 0.035) at rest. Mann-Whitney U test showed significant differences between raters for -10° and -15° MII and between 8% and 4% LAFH ratio at rest. CONCLUSIONS: All groups rated -5° inclinations to be most attractive. General dentists and orthodontic residents found normal LAFH to be the most attractive, whereas long facial height was less attractive with smile. In addition, smile had a camouflaging effect on LAFH.

Knowledge and awareness of dental specialists, general dentists and dental assistants regarding SARS­CoV­2.

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2) has had drastic effects among healthcare professionals. OBJECTIVES: This study aimed to assess knowledge and awareness among dental specialists, general dentists and dental assistants regarding standard patient care guidelines for minimizing the spread of the infection. MATERIAL AND METHODS: A survey-based cross-sectional study was conducted on a sample of 84 participants. The participants were divided into groups of dental specialists, general dentists and dental assistants. A modified version of a validated questionnaire was used to evaluate knowledge and awareness regarding SARS­CoV­2 as per the Centers for Disease Control and Prevention (CDC) guidelines. Data was analyzed using the one-way analysis of variance (ANOVA) and post-hoc Tukey's tests to assess differences in knowledge regarding the SARS­CoV­2 guidelines across the 3 groups. The simple linear regression analysis was used to examine factors influencing the knowledge scores. RESULTS: Among all dental specialists, 13 orthodontists, 9 operative dentists, 8 maxillofacial surgeons, 4 prosthodontists, and 1 periodontist responded to the survey. The mean knowledge scores of dental specialists, general dentists and dental assistants were 10.05 ±2.10, 9.95 ±2.30 and 8.53 ±2.10, respectively. Overall, we found a significant difference (p = 0.02) in the knowledge scores between the groups, and pairwise comparisons showed that there was a significant difference (p = 0.03) in the knowledge scores between dental specialists and dental assistants. CONCLUSIONS: These findings suggest that hospitals should conduct mandatory workshops, training sessions and seminars to raise the awareness of the novel coronavirus pandemic and disinfection protocols, not only for specialists, but for all staff members.

Cephalometric predictors for optimal soft tissue profile outcome in adult Asian class I subjects treated via extraction and non-extraction. A retrospective study.

OBJECTIVE: The aim of this retrospective study was to identify cephalometric predictors associated with favourable soft tissue profile outcomes after premolars extraction and non-extraction in class I malocclusion subjects. MATERIALS AND METHODS: A total of 80 subjects, treated with non-extraction and premolars extraction (40 subjects each), were equally divided into favourable (FG) and unfavourable (UFG) groups using subjective and objective soft tissue profile outcome assessment methods. An independent t-test was utilized for the comparison of cephalometric measurements between the non-extraction (NE) and premolars extraction (PME) treatment modalities. Cox proportional hazard algorithm regression analysis was performed to identify cephalometric factors associated with favourable soft tissue outcomes. RESULTS: The pre-treatment mean age of the NE group was 20.2±2.3 and PME group was 20.2±2.5 years. After dividing the sample of the NE and PME groups according to subjective and objective soft-tissue outcome assessment criteria, FG and UFG consisted of 20 subjects each. Cox proportional hazard algorithm regression analysis found upper incisor to NA angle (95% CI: 1.033, 1.196) to be associated with FG in NE and upper incisor to SN (95% CI: 1.018, 1.206) and ANB angle (95% CI:1.165, 3.608) in PME. There was a statistically significant strong correlation between subjective and objective evaluation methods (P≤0.001). CONCLUSIONS: Cephalometric analysis is a valuable tool to predict soft-tissue outcomes after NE and PME. Increased upper incisors inclinations at the start of NE treatment result in favourable soft tissue profile outcomes. Slightly convex profile and proclined maxillary incisors are the predictors of favourable soft tissue profile outcome after PME. There was a statistically significant association between subjective and objective evaluation criteria of soft tissue outcomes.