ABSTRACT
Oxidative stress is a common pathology seen in approximately half of all infertile men. Peroxides causing infertility are generated by sperm and seminal leukocytes. Oxidative stress occurs when production of potentially destructive reactive oxygen species exceeds natural antioxidant defenses resulting in cellular damage. The causes of the oxidative stress include environmental factors (phthalates et al.), chronic inflammation of the prostate, varicocele, autoimmune response to seminal antigens.
Subject(s)
Antioxidants/metabolism , Infertility, Male/metabolism , Oxidative Stress , Reactive Oxygen Species/metabolism , Spermatozoa/metabolism , Adolescent , Adult , Autoimmune Diseases/metabolism , Autoimmune Diseases/pathology , Autoimmune Diseases/physiopathology , Chronic Disease , Humans , Infertility, Male/pathology , Infertility, Male/physiopathology , Inflammation/metabolism , Inflammation/pathology , Inflammation/physiopathology , Male , Middle Aged , Spermatozoa/pathologyABSTRACT
A more than 80% incidence of herpes simplex virus, cytomegalovirus, and chlamydial infection was revealed in 58 patients with various gynecological diseases. In 50% cases the infection was mixed. An appreciable reduction of the gamma-interferon system was detected in 20 patients, which was caused by a concomitant infectious process, possibly provoking the development of the underlying disease. Treatment of such patients should include antiviral and antichlamydial therapy, as well as correction of defects in interferon production.
