ABSTRACT
An analysis of results of experiments on the assessment of morphofunctional properties of the bacterio-contaminated blood has been made. A conclusion is drawn that it is expedient to use hemosorption in order to provide safe reinfusion in patients with massive blood loss and injury of hollow organs of the abdomen.
Subject(s)
Abdominal Injuries/complications , Blood Transfusion, Autologous , Enterobacteriaceae Infections/prevention & control , Hemoperfusion/methods , Hemorrhage/therapy , Sepsis/therapy , Abdominal Injuries/microbiology , Animals , Enterobacteriaceae Infections/etiology , Hemorrhage/etiology , RabbitsABSTRACT
To study the transport kinetics, 10 experiments on canine isolated lung preparations were performed using tritium-labeled lipopolysaccharide, Evans blue dye, fluorescein and tritium-labeled water as mass transfer markers. The markers with high molecular weight were more rapidly transported through interstitium than those with low molecular weight. The data obtained corroborate the thesis that the distribution of substances in the interstitium follows the laws of diffusion and convection in porous phase. Active functioning of the endothelium structures also affects the blood-to-lymph transport.
Subject(s)
Blood/metabolism , Lung/metabolism , Lymph/metabolism , Animals , Biological Transport , Biomarkers/blood , Chemical Phenomena , Chemistry , Dogs , Endothelium/metabolism , Female , In Vitro Techniques , Kinetics , Male , Molecular Weight , TritiumABSTRACT
The authors have demonstrated activation of the Kallikrein-Kinin system in critical states and ways to decrease the level of its components in hemosorption. It was shown in experiments in 15 dogs and 120 rats (in blood loss and endotoxin shock) and in 12 patients (with acute pneumonia, Mendelson syndrome and "shock lung").