ABSTRACT
Worn shoes contribute to injuries caused by slip-and-fall accidents. The peak required coefficient of friction (RCOF) has been associated with tread wear rate. However, the temporal relationship between RCOF and shoe wear is unknown. The purpose of this study was to determine whether the contact region at the time of peak RCOF is consistent with the region of shoe wear. The shoe contact region at peak RCOF was imaged by frustrated total internal reflection. Images of worn tread after months of use were captured. The worn tread region was more posterior than the contact region at RCOF and did not correlate with the contact region at the time of RCOF. The contact regions observed during earlier stance (within 83 ms of heel contact) were more consistent with the worn region, suggesting that RCOF may not directly cause tread wear. These results serve to motivate future studies to identify early-stance gait parameters associated with tread wear development.
ABSTRACT
Blood vessels form intricate networks in 3-dimensional space. Consequently, it is difficult to visually appreciate how vascular networks interact and behave by observing the surface of a tissue. This method provides a means to visualize the complex 3-dimensional vascular architecture of the lung. To accomplish this, a catheter is inserted into the pulmonary artery and the vasculature is simultaneously flushed of blood and chemically dilated to limit resistance. Lungs are then inflated through the trachea at a standard pressure and the polymer compound is infused into the vascular bed at a standard flow rate. Once the entire arterial network is filled and allowed to cure, the lung vasculature may be visualized directly or imaged on a micro-CT (µCT) scanner. When performed successfully, one can appreciate the pulmonary arterial network in mice ranging from early postnatal ages to adults. Additionally, while demonstrated in the pulmonary arterial bed, this method can be applied to any vascular bed with optimized catheter placement and endpoints.
