[Isoflavones and calcified tissues]. / Izoflavony i sistema obyzvestvlennykh tkanei.

The data about osteotropic action of isoflavones are presented in this review. Isoflavones are the compounds of phytoestrogenes group--hormone-like bioregulators of plant origin. Animal experiments as well as bone tissue and bone cells cultures investigations demonstrate anabolic effect of isoflavones on bone metabolism. Isoflavones prevent bone loss in ovariectomized animals. They inhibit bone resorbition and enhance bone formation. Because of this natural and synthetic isoflavones hold great promise in the prevention and treatment of osteoporosis. These compounds may also be effective in preventing bone loss associated with hypodynamia or immobility, ovariectomy or postmenopausal hypoestrogenia, chronic corticosteroid use, renal osteodystrophy, hyperparathyroidism and other metabolic disorders affecting the calcified tissues, including alveolar bone loss in periodontal disease as well as dental hard tissues destruction.

[The effect of Biotrit balsam and Biotrit C on the level of health]. / Vliianie bal'zama "Biotrit" i Biotrita C na uroven' zdorov'ia.

The study was made in forty subjects, their health level being assessed as recommended by G. L. Apanasenko as well as by modification of his method. The results obtained showed the health level of those enrolled in the study to have gotten increased with administration of Biotrit C and balsam "Biotrit" during 20 days. The effect was found out to be maintained for 20 days after the drug had been withdrawn. The obtained results permit recommending Biotrit C and balsam "Biotrit" as adaptogens.

[Effect of salivary gland stimulation by sialadenotrophic influences on the development of stress ulcers of the stomach in rats]. / Vliianie stimuliatsii sliunnykh zhelez sialadenotroficheskimi vozdeistviiami na razvitie stressovykh iazv zheludka u krys.

It was demonstrated in experiments on female Wistar rats that transient hypertrophy of the salivary glands (the sialadenotrophic effect) induced by trypsin ingestion or repeated amputation of the lower incisors inhibits the development of stress erosive-ulcerating lesions of the gastric mucosa (GM). Stimulation of the salivary glands by sialadenotrophic effects caused an increase of the depth of the gastric pits and the height of the surface-foveolar epithelium responsible for mucus production, as well as a reduction in the number of parietal cells per unit of area of GM section.

[Role of adrenergic receptors in the mechanism of action of catecholamines and DOPA on proliferative processes]. / Rol adrenergicheskikh retseptorov v mekhanizme vliianiia katekholaminov i DOFA na proliferativnye protsessy.

Catecholamines (adrenaline, isoproterenol) and L-DOPA decreased the mitotic index of L-cells in culture. The action of catecholamines was blocked by the beta-adrenergic antagonist propranolol, but was not abolished by the alpha-adrenoblocker phenoxybezamine. The L-DOPA-induced decrease in the mitotic index did not depend on the pretreatment with the adrenoblockers. Catecholamines inhibited the incorporation of 3H-thymidine and 3H-leucine into DNA and total protein of the cells, respectively. Preincubation of the culture with propranolol for 10-20 minutes before catecholamine administration prevented the action of catecholamines. Phenoxybenzamine, an alpha-adrenoreceptor blocker, did not produce such an effect. The data obtained point to the leading role of beta-adrenoreceptors in the mechanism of the effects of catecholamines on proliferative processes. The action of L-DOPA on cell proliferation does not seem to be linked with adrenoreceptor activation.

[Reaction of the rat submandibular gland to repeated amputations of the lower and upper incisors (a morphometric study)]. / Reaktsiia podnizhnecheliustnoi sliunnoi zhelezy krys na povtornye amputatsii nizhnikh i verkhnikh reztsov (morfometricheskoe issledovanie).

It has been stated in experiments performed on Wister rats, that periodic amputation both of lower and upper incisor teeth results in hypertrophy of the submandibular salivary glands. However, when the upper incisors are extirpated, the enlargement of the gland is less pronounced, especially in the males. The leading role in the reaction plays the increasing size of the acinar cells, but certain ductal elements (especially striated ducts) also react by increasing their diameter in response to the trauma both in the lower and upper incisors.

[Urinary excretion of vanilmandelic acid in the glossalgia syndrome]. / Kharakter ékskretsii vanililmindal'noi kisloty s mochoi pri sindrome glossalgii.

Under observation there were 78 patients aged 41 to 70 years suffering from the glossalgia syndrome, as well as 25 clinically healthy subjects. An activation of the sympathoadrenal system was revealed in the patients. This was ascertained on the basis of the data on vanillylmandelic acid excretion with the urine. The excretion of that acid is known to be dependent on the intensity of the paraesthesias, the duration of the ailment and the character of concurrent visceral diseases. The results obtained are regarded as evidences of the participation of the vegetative nervous system in the mechanism of the glossalgia syndrome development.