ABSTRACT
Problem drinking, which may be more prominent among young adults, is associated with mental and physical complications. The onset, use, and abuse of alcohol may be related to personality traits such as agreeableness, neuroticism and extraversion. This study aimed to examine the relationship between personality traits and alcohol use among undergraduates in southwest Nigeria. This was a cross-sectional study carried out among undergraduates in southwestern Nigeria. Four hundred and twelve (412) students were recruited using multi-stage random sampling from the total full-time student population. Each participant completed Alcohol Use Disorder Identification Test (AUDIT) and Big Five Inventory-10 (BFI-10). The result showed that the lifetime prevalence of alcohol use was 31.8% while 10.8% were involved in problem drinking. Also, there was an association between alcohol use, male gender and parental history of psychoactive substance use. Out of the 5 personality traits, the extraversion trait was higher among drinkers (P = 0.001) while agreeableness was significantly lower among drinkers (P = 0.033). Extraversion trait was significantly higher in respondents involved in problem drinking (P < 0.001). The predictors of problem drinking in this study were extraversion trait and male gender. The study suggests there are intervening factors mediating personality traits and problem drinking among undergraduates.
ABSTRACT
Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.
