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Ross Fiziol Zh Im I M Sechenova ; 83(11-12): 19-28, 1997.
Article in Russian | MEDLINE | ID: mdl-9541953

ABSTRACT

Administration of IL-1 beta and 125-129 fragment of alpha 2-interferon improved learning and retention of active avoidance behaviour in memory in rats. It also improved the correlation between intersignal runs and success of the avoidance behaviour learning. The data obtained suggest that an activation of the intersignal retention process is one of the mechanisms of the immunomodulators effect on learning and memory.


Subject(s)
Adjuvants, Immunologic/pharmacology , Avoidance Learning/drug effects , Escape Reaction/drug effects , Interferon Type I/pharmacology , Interleukin-1/pharmacology , Memory/physiology , Neuroimmunomodulation/drug effects , Peptide Fragments/pharmacology , Animals , Avoidance Learning/physiology , Conditioning, Psychological/drug effects , Escape Reaction/physiology , Exploratory Behavior/drug effects , Interferon-alpha , Male , Neuroimmunomodulation/physiology , Rats , Rats, Wistar , Reaction Time/drug effects , Recombinant Proteins , Systems Theory , Vocalization, Animal/drug effects
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