[Characteristics of student response to pandemic in cross-cultural context]. / Osobennosti reagirovaniya studentov pri pandemii v krosskul'tural'nom kontekste.

OBJECTIVE: Of the work is a cross-cultural analysis of the characteristics of student response in a pandemic situation. MATERIAL AND METHODS: The sample consisted of students of NSMU and the Kazakh National University. Al-Farabi in the amount of 37 people aged 20 to 23; The battery of psychological methods was compiled by Spielberger and Khanina; Mississippi Post-Traumatic Stress Disorder Scale (civil version) and PSM-25 Psychological Stress Scale. RESULTS: 52.7% of respondents showed an average level of stress, 47.3% - a low level, which indicates insufficient psychological adaptation to psychological stress. High rates of personal and situational anxiety were diagnosed in 67.57% of cases; the average level of reactive anxiety - in 29.73% of cases and personal - in 27.03% of respondents. The majority of respondents showed average levels of post-traumatic stress reactions (50%, n=37), while a low level of post-traumatic stress reactions occurs in 11 (14.87%) people, a low level - in 17 (22.97%) people and increased - in 9 (12.16%) people. Stress level indicators tend to have significant differences: the frequency of occurrence of average stress indicators in the sample of students from Kazakhstan is higher (75.6%) compared to Russian students (24.32%) (p<0.05).Adapting to changing academic workloads in a pandemic situation does not contribute to the psychological well-being of students, as evidenced by the results of diagnosing anxiety and post-traumatic stress reactions. The results obtained emphasize the importance of taking into account cultural factors in stressful situations. CONCLUSION: Cross-cultural differences in the level of emotional response of students in a pandemic situation were revealed.

Influence of Surgical Treatment and Neoadjuvant Therapy of Chemically Induced Breast Cancer on Correlation of Cytokine Concentrations in the Lymph with Structural Transformations in the Mesenteric Lymph Nodes.

We performed a correlation analysis of the morphometry of mesenteric lymph nodes and cytokines of the thoracic duct lymph in chemically induced breast cancer (BC) and after surgical treatment of BC and neoadjuvant chemotherapy for BC according to the CMF scheme. After surgical treatment, correlations were found between the level of cytokines in the thoracic duct lymph and morphological changes in the mesenteric lymph nodes. The observed correlations can be a result of total resection of the tumor and increased immunomodulatory and antitumor action of cytokines. Comparison of the effect of chemotherapy and surgical treatment revealed correlations between cytokine concentrations in the lymph and structural changes in the lymph nodes, which can be related to weakening of local immunity and antitumor effect of cytokines.

[Dynamics of personality characteristics in the process of psychocorrective intervention in drug addicts]. / Lichnostnye osobennosti patsientov s narkozavisimost'yu i ikh izmeneniya v protsesse psikhokorrektsionnogo vmeshatel'stva.

OBJECTIVE: To study the dynamics of personality features and features of self-release in drug addicts. MATERIAL AND METHODS: We examined 10 drug-dependent patients with whom psycho-correctional work was carried out, 10 drug-dependent patients with whom correctional work was not carried out, and 20 healthy young people. All participants were men aged 20 to 24 years. Personality characteristics were determined by Cattell's 16PF questionnaire and a set of psychological tests. Correction work was carried out by a psychologist (7 sessions, one hour each). In these cases, the patients were examined before and after psychocorrectional intervention. RESULTS: The high levels of sociability, self-esteem and expressiveness combined with low intelligence were identified in drug addicts compared with healthy people. Drug addicts are willing to accept themselves and are interested in their own personality. CONCLUSION: This study is of practical importance and can be used as a material for dealing with people with addictive behavior.

[The severity of neurotic disorders and social masochism in chemical addicts]. / Vyrazhennost' nevroticheskikh rasstroistv i sotsial'nogo mazokhizma u bol'nykh s khimicheskoi addiktsiei.

OBJECTIVE: To study symptoms of neurotic disorders and social masochism in chemical addicts. MATERIAL AND METHODS: Thirty outpatients of the Novosibirsk Regional Clinical Addiction Dispensary were studied. Corresponding scales and questionnaires, along with a social masochism questionnaire developed by the authors, were used. Results were compared to those of 25 healthy people. RESULTS AND CONCLUSION: A significantly higher level (p≤0.05) of the following neurotic disorders: sleep disturbances, hysterical neurotic disorder, anxious neurotic disorder, social maladaptation and depressive neurotic disorder as well as a subclinical level of anxiety and depression were observed in chemical addicts. Moreover, patients with chemical dependence revealed significantly higher (p≤0.05) indicators of aggression, victim behavior and social masochism (different types of aggression, victimization, irritability, negativism, resentment, guilt, self-harming behavior, hypersocial behavior, provoking and uncritical behavior, the role of the victim, negative perception and a general indicator of social masochism). The correlations between indicators of the affective sphere, manifestations of social masochism and neurotic disorders in individuals with chemical dependence were identified.

[Social-psychological characteristics of different types addictive behavior]. / Sotsial'no-psikhologicheskie kharakteristiki pri formirovanii addiktivnogo povedeniia.

AIM: To study social-psychological predictors of different types of addictive behavior. MATERIAL AND METHODS: Thirty-six patients, aged 22-50 years, with different addictions (nicotine dependence, alcohol dependence, drug dependence, Internet addiction, extreme sports addiction) were studied. A questionnaire for assessment of personality accentuation, the Life Style Index, The world assumptions scale and the Rokeach Value Survey were administered. RESULTS AND CONCLUSION: Social-psychological predictors of the types of addictive behavior were identified.

[The relationship between the family structure and characteristics of the stress reaction in adolescent addicts]. / Sviaz' semeinoi struktury i osobennostei reagirovaniia na stress u podrostkov-addiktov.

AIM: To study the relationship between the family structure and characteristics of the response to stress in adolescent addicts. MATERIAL AND METHODS: The study included 65 patients who used psychoactive substances and 42 healthy controls. A set of psychological methods was used. RESULTS AND CONCLUSION: In the group of adolescent addicts, a low result was revealed on the scale 'family cohesion'. A high level of development of such mechanisms of psychological defense as denial, suppression, repression, compensation, substitution, intellectualization and reactive education was diagnosed in both groups. Significant differences were revealed only in repression. Such stress coping strategies as self-control, escape-avoidance and problem-solving were more often used in the main group while confrontational coping, distancing, seeking social support, accepting responsibility and positive reassessment were used in the control group. Lower indices of resilience in adolescent addicts compared to the control group.

[Cell phenotypes of a mutant in the gene encoding a Rad51 paralog in fission yeast].

The discovery of three Rad51 paralogs in Saccharomyces cerevisiae (Rad55, Rad57, and Dmc1), four in Schizosaccharomyces pombe (Rhp55, Rhp57, Rlp 1, and Dmc 1), and six in human (Rad51 B, Rad51 C, Rad51 D, Xrcc2, Xrcc3, and Dmcl) indicate the functional diversity and specialization of RecA-like proteins in the line from the lower to higher organisms. This paper reports characterization of a number of mitotic and meiotic phenotypes of the cells mutant in rlpl gene, encoding a paralog of Rad5 1, in fission yeasts. No evident role of Rlp I protein in the repair of spontaneous lesions emerging during mating type switching was found. Rlpl does not interact physically with Dmcl. An elevated expression of rhp51 has a dominant negative effect on the cell survivability of rlpl mutant exposed to a DNA-damaging agent. We assume that Rlp 1 acts at the stages of recombination connected with disassembling of the nucleoprotein filament formed by Rhp51 protein.

[The activity of natural killer cells in healthy and tumor-bearing mice after treatment with low-intensity laser light].

The effect of low-intensity laser light on the activity of natural killer cells from healthy and tumor-bearing mice was studied. Skin in the zone of the thymus or hind limb was illuminated, the remaining body surface being screened. The illumination was carried out for 30 days, with the duration of a single exposure being 1 min and intervals between the exposures being 48 h. The effect of laser light depended on the location of the illuminated area. It was shown that the exposure of the thymus of healthy animals for 20 and 30 days leads to a significant decrease in the activity of natural killer cells. On the contrary, the illumination of the limb for 10 or 20 days increased the activity of natural killer cells; but when hind limbs were treated for 30 days, the activity of natural killer cells decreased. Whereas tumor growth increased the natural killer cell activity, the illumination of tumor-bearing mice lowered the adaptive antitumoral resistance by decreasing the activity of natural killer cells.