[The influence of the androgens on the process of the experimental diabetes and the activity of the synthesis of the nucleic acids in the male rats liver].

The aim of this research is to study the dependence the gravity of diabetes course and the activity of the biosynthetical processes in the liver from the level of the sexual steroides in the male-rats blood on the model of the alloxan diabetes. The experiments were carried out on 80 male rats (weight 180-200g). The diabetes has been reproduced by the single injection of alloxan per 200mg/kg. The content of glucose, testosterone, estradiole and corticosterone have been determined in the blood of the animals. Activity of the syntheses of the nucleic acids in the liver has been researched by the radiometrical method on 14, 30, 45 and 90 days of the experiment. On all stages of the observation has been revealed the inverse relation between the concentration of the testosterone in the blood and the gravity of the experimental diabetes which was determined by the degree of hyperglycemya and the changes of the coefficient of sexual hormones ratio, the content of estradiol, corticosterone and activity of the syntheses of the nucleic acids in the tissue of the liver. The injection of the androgen during two week caused jump increasing the testosterone concentration, approaching the sexual steroids ratio to the norm, decreasing the glucose, estradiole, corticosterone content and also the reduction the nucleic acids syntheses activity in the liver. It was shown the positive influence of the androgens on development of the compensatory processes in the male rats, which course the decrease the experimental diabetes gravity.

[Modulating effects of androgens on development adaptive-compensatory processes in organism of experimental animals-males].

The purpose of research is the definition of androgens role and myocardial androgen receptors and sex steroids in males under metabolic and hormonal "stress" induced by the experimental diabetes. Research was carried out on 60 rats-males, mass 180,0-200,0 g. The diabetes reproduced by single injection of alloxan (200mg/kg). Androgen receptors were revealed by the radiometric and radioautography methods. The content of glucose, immunoreactive insulin, testosteron, estradiol, corticosteron and somatotropin were defined in animals blood plasma. On the early terms of alloxan diabetes estradiol concentration increase against a background of testosteron decrease which causes the "feminization" of the sexual hormonal balance. On the other side the increase of androgen receptors expression by cardiomyocytes causes the intensification of myocardium tissue physiologic ability to androgens perception positively influencing on the metabolism. Consequently, androgens provoke stimulating effect on the myocard metabolism in males at early stages of the experimental diabetes.

[Morphological structure of suprarenal glands in experimental vibration-induced pathology].

Technical progress has caused development of vibration-induced pathology, which is determined by harmful factors or environmental effects. The harmful factors include physical factors--noise, mechanical vibrations, low temperature, high humidity of the air and incorrect lighting. The aim of our study was the investigation of morphological changes in suprarenal glands under condition of vibration-induced pathology. The experiment was conducted on 20 grown-up white male rats weighting 180-200 g. The animals were daily under an hour vibration during 2 months. The vibration frequency was modulated by means of a general vibration. After an experiment, animals were decapitated in condition of general anesthesia. The experiment revealed important changes in the morphological structure of suprarenal glands. The vibration pathology causes following changes: vessels' and sinusoid capillaries' uneven widening, develop the infiltrate cells, bleeding areas, necrosis and other changes. Based on above-stated it is supposed that technical progress and introduction of new technologies is one of the risk factors, which can cause neurohumoral disorders.

[The role of some pituitary hormones in patients with non-insulin-dependent diabetes mellitus and diabetic retinopathy].

The level of somatotropin and thyreotropin hormones was measured in blood plasma of patients with non-insulin-dependent diabetes mellitus with and without diabetic retinopathy (DR). Fifty eight patients (26 males and 32 females) aged from 35 to 75 were examined. The patients were divided into two groups. First group included 29 patients (13 males and 16 females) with non-insulin-dependent diabetes mellitus without DR. Second group included the same number of patients with non-insulin-dependent diabetes mellitus complicated by DR. The concentration of somatotropin hormones was increased and thyreotropin was decreased in patients with non-insulin-dependent diabetes mellitus with DR. The results suggest that somatotropin and thyreotropin contributes to the development of diabetic retinopathy in humans.