Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 19 de 19
Filter
1.
J Chemother ; 22(2): 110-4, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20435570

ABSTRACT

Tigecycline is a promising therapeutic option against many current multidrug resistant pathogens. The aim of this retrospective study was to determine the clinical and microbiological outcomes of patients treated with tigecycline for serious infections caused by carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex (Acb-complex). A retrospective study was conducted to define the patients who received tigecycline for carbapenem-resistant Acb-complex infections between 1 June, 2008 and 1 may, 2009. A total of 21 patients were eligible for the study. The median age of the patients was 48 years and 6 patients were female. Eighteen patients were treated with tigecycline for carbapenemresistant Acb-complex as the sole microorganism while 3 received it for polymicrobial infections. All Acb-complex isolates were susceptible to tigecycline. The most common indication of tigecycline treatment was surgical-site infections (SSI) followed by ventilator associated pneumonia (VAP). Tigecycline was the sole antibiotic administered in 7 patients while concurrent antibiotics were used in 14 patients. The median duration of tigecycline therapy was 14 days. Two patients died within 14 days of initiating treatment, representing an attributable mortality rate of 9.5% while 4 patients died within 30 days representing a crude mortality rate of 19.1%. Seventeen out of 21 patients had successful clinical outcomes, cure in 11 patients and improvement in 6. Fourteen of 21 patients had microbiological failure. Correlation between microbiological response with clinical outcome was poor. Clinical failure was more common in patients with VAP. Patients with bacteremia were more likely to have microbiological failure while microbiological outcome was better in patients with SSI. In this retrospective study, 81% (17 of 21) of the patients infected with carbapenem-resistant Acb-complex had a positive outcome under tigecycline therapy. However, these preliminary results should be evaluated cautiously in the absence of well-controlled studies.


Subject(s)
Acinetobacter Infections/drug therapy , Anti-Bacterial Agents/therapeutic use , Carbapenems/pharmacology , Drug Resistance, Multiple, Bacterial , Minocycline/analogs & derivatives , Acinetobacter baumannii/drug effects , Acinetobacter calcoaceticus/drug effects , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Minocycline/therapeutic use , Retrospective Studies , Tigecycline , Young Adult
2.
J Chemother ; 21(4): 383-9, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19622455

ABSTRACT

Resistance rates to amikacin, ciprofloxacin, ceftazidime, cefepime, imipenem, cefoperazone/sulbactam and piperacillin/tazobactam in Escherichia coli (n= 438), Klebsiella pneumoniae (n= 444), Pseudomonas aeruginosa (n= 210) and Acinetobacter baumanni (n=200) were determined with e-test in a multicenter surveillance study (Hitit-2) in 2007. ESBL production in Escherichia coli and K. pneumoniae was investigated following the CLSI guidelines. Overall 42.0% of E.coli and 41.4% of K. pneumoniae were ESBL producers. In E. coli , resistance to imipenem was not observed, resistance to ciprofloxacin and amikacin was 58.0% and 5.5% respectively. In K. pneumoniae resistance to imipenem, ciprofloxacin and amikacin was 3.1%, 17.8% 12.4% respectively. In P. aeruginosa the lowest rate of resistance was observed with piperacillin/tazobactam (18.1%). A. baumanni isolates were highly resistant to all the antimicrobial agents, the lowest level of resistance was observed against cefoperazone/sulbactam (52.0%) followed by imipenem (55.5%). this study showed that resistance rates to antimicrobials are high in nosocomial isolates and show variations among the centers.


Subject(s)
Anti-Infective Agents/pharmacology , Drug Resistance, Multiple, Bacterial , Gram-Negative Bacteria/drug effects , Gram-Negative Bacterial Infections/microbiology , Gram-Negative Bacteria/enzymology , Gram-Negative Bacteria/isolation & purification , Gram-Negative Bacterial Infections/epidemiology , Humans , Intensive Care Units , Microbial Sensitivity Tests , Population Surveillance , Turkey/epidemiology , beta-Lactamases/metabolism
4.
Clin Microbiol Infect ; 13(10): 1023-5, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17608812

ABSTRACT

The aims of this study were to detect BRO beta-lactamase types and to evaluate any correlation with the susceptibility patterns of 90 clinical isolates of Moraxella catarrhalis. The overall prevalences of the bro-1 and bro-2 genes were 78% and 12%, respectively. Penicillin G MICs for BRO-1+ isolates were significantly higher than those for BRO-2+ isolates. All the isolates were susceptible to amoxycillin-clavulanate, levofloxacin and cefixime. Resistance to clarithromycin, tetracycline and trimethoprim-sulphamethoxazole was 1.1%, 2.2% and 1.1%, respectively. One-step, length-based PCR was an efficient method to screen for BRO beta-lactamase genes.


Subject(s)
Anti-Bacterial Agents/pharmacology , Moraxella catarrhalis/drug effects , Moraxellaceae Infections/microbiology , beta-Lactamases/genetics , beta-Lactams/pharmacology , DNA, Bacterial/analysis , DNA, Bacterial/genetics , Drug Resistance, Bacterial , Humans , Microbial Sensitivity Tests , Moraxella catarrhalis/enzymology , Moraxella catarrhalis/isolation & purification , Polymerase Chain Reaction/methods , beta-Lactamases/classification , beta-Lactamases/metabolism
5.
Clin Microbiol Infect ; 11(6): 495-9, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15882201

ABSTRACT

Predisposing factors, antimicrobial susceptibility patterns, treatment and outcome were analysed for nine consecutive patients with nocardiosis. Predisposing factors were identified in six (67%) of the nine patients. Clinical syndromes of nocardial infection were pulmonary infection (three patients), cerebral infection (five patients) and disseminated infection (one patient). The predominant (60%) species was Nocardia farcinica rather than the Nocardia asteroides complex. Treatment was started empirically, modified according to the antimicrobial susceptibility pattern, and then continued for 6-12 months. Overall mortality was 33%, with death being caused by the Nocardia infection in two cases.


Subject(s)
Nocardia Infections/therapy , Nocardia/isolation & purification , Adult , Amikacin/pharmacology , Anti-Bacterial Agents/pharmacology , Brain Abscess/pathology , Brain Abscess/surgery , Causality , Ceftriaxone/therapeutic use , Fatal Outcome , Female , Hospitals, Teaching , Humans , Imipenem/pharmacology , Lung Diseases/drug therapy , Lung Diseases/pathology , Male , Microbial Sensitivity Tests , Nocardia/drug effects , Nocardia Infections/epidemiology , Nocardia Infections/pathology , Retrospective Studies , Turkey/epidemiology
6.
Eur J Clin Microbiol Infect Dis ; 24(3): 220-5, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15772822

ABSTRACT

Since Turkey currently lacks a national reference center for Salmonella infections, the present study was conducted to document the distribution of serotypes and antimicrobial resistance patterns among Salmonella enterica isolates recovered from clinical samples in ten Turkish provinces over a 2-year period. Among the 620 Salmonella enterica isolates recovered between 1 July 2000 and 30 June 2002, strains belonging to the serotypes Enteritidis (47.7%), Typhimurium (34.7%), Paratyphi B (6.0%), Typhi (2.9%), Paratyphi A (0.2%) and serogroup C (8.5%) were found. Resistance to multiple antimicrobial agents was particularly high among Salmonella Typhimurium isolates (76.7%), and resistance or decreased susceptibility to ciprofloxacin (MIC> or =0.125 mg/l) was demonstrated in Salmonella Paratyphi B, Salmonella Typhimurium and Salmonella Enteritidis strains. All of the Salmonella Typhi isolates were susceptible to ciprofloxacin. The results indicate that decreased susceptibility to ciprofloxacin is an emerging problem in Salmonella enterica in Turkey, particularly in multiresistant strains.


Subject(s)
Anti-Bacterial Agents/pharmacology , Drug Resistance, Bacterial , Salmonella enterica/drug effects , Humans , Microbial Sensitivity Tests , Prospective Studies , Salmonella Infections/epidemiology , Salmonella Infections/microbiology , Salmonella enterica/classification , Serotyping , Turkey/epidemiology
7.
Clin Microbiol Infect ; 10(4): 309-14, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15059119

ABSTRACT

In total, 177 patients with bloodstream infections caused by Staphylococcus aureus (BSISA) were investigated prospectively between June 1999 and June 2001. Of these, 19.8% had community-acquired BSISA, while 80.2% had nosocomial BSISA. Surgical intervention, foreign body, mechanical ventilation, total parenteral nutrition, and previous antibiotic treatment were found to be important risk factors for the nosocomial BSISA group. Secondary BSISA formed a greater proportion (62.9%) of community-acquired infections than of nosocomial infections (26.8%; p 0.0001). Catheter-related nosocomial BSISA was observed in 72.1% of patients. The suppurative complication rate was significantly higher among community-acquired infections (22.9%) than among nosocomial infections (6.3%; p 0.008). Of the nosocomial BSISA, 65.5% were methicillin-resistant. Analysis of 80 methicillin-resistant S. aureus isolates by pulsed-field gel electrophoresis identified ten main clones (A-J), but 61 (76.3%) of the 80 isolates belonged to clone A.


Subject(s)
Bacteremia/microbiology , Bacteremia/physiopathology , Hospitals, University , Methicillin Resistance , Molecular Epidemiology , Staphylococcus aureus/isolation & purification , Adult , Aged , Aged, 80 and over , Community-Acquired Infections/epidemiology , Community-Acquired Infections/microbiology , Cross Infection/epidemiology , Cross Infection/microbiology , Electrophoresis, Gel, Pulsed-Field , Female , Humans , Male , Middle Aged , Prospective Studies , Staphylococcal Infections/microbiology , Staphylococcal Infections/physiopathology , Staphylococcus aureus/drug effects , Staphylococcus aureus/genetics , Turkey/epidemiology
8.
Clin Microbiol Infect ; 9(10): 1038-44, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14616749

ABSTRACT

The aims of this prospective study were to: (1) determine the rate of blood culture contamination; (2) describe and compare the epidemiologic, clinical and microbiological characteristics of hospital- and community-acquired bloodstream infections; and (3) determine the mortality resulting from bloodstream infections. The rate of true bacteremia was 12.1%, and 10.7% of cultures were contaminated. Of the 567 episodes of bloodstream infection, 73.4% were hospital-acquired, and 26.6% were community-acquired. The most commonly isolated microorganisms were staphylococci (44%, methicillin resistant 69.4%), enterococci (15%) and Escherichia coli (12.5%) in hospital-acquired episodes, and Brucella spp. (21.9%), E. coli (19.2%) and Staphylococcus aureus (14.6%, methicillin resistant 9.1%) in community-acquired episodes. While the overall mortality rate was 25.4%, death attributable to bloodstream infections was 16.6% in hospital-acquired episodes and 13.9% in community-acquired episodes. The highest mortality occurred in patients with bacteremia due to Pseudomonas aeruginosa (37.5%) in hospital-acquired episodes, and in patients with bacteremia due to Streptococcus pneumoniae (50%) in community-acquired episodes. Underlying diseases, severity of illness, presence of bladder catheter, previous use of antibiotics, tracheal intubation and adequacy of treatment were found to be significantly associated with death.


Subject(s)
Bacteremia/microbiology , Blood/microbiology , Community-Acquired Infections/microbiology , Cross Infection/microbiology , Bacteremia/blood , Bacteremia/epidemiology , Bacteremia/mortality , Brucellosis/blood , Brucellosis/epidemiology , Brucellosis/microbiology , Brucellosis/mortality , Community-Acquired Infections/epidemiology , Community-Acquired Infections/mortality , Cross Infection/blood , Cross Infection/epidemiology , Cross Infection/mortality , Escherichia coli Infections/blood , Escherichia coli Infections/epidemiology , Escherichia coli Infections/microbiology , Escherichia coli Infections/mortality , Hospital Mortality , Humans , Incidence , Prospective Studies , Staphylococcal Infections/blood , Staphylococcal Infections/epidemiology , Staphylococcal Infections/microbiology , Staphylococcal Infections/mortality , Turkey/epidemiology
9.
J Hosp Infect ; 50(3): 170-4, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11886191

ABSTRACT

At the end of 1999, a case of polymicrobial ventriculitis in the Department of Neurosurgery followed by an outbreak of Serratia marcescens mediastinitis in the intensive care unit of cardiovascular surgery occurred. These nosocomial surgical infections were considered to be the result of contamination of surgical sites with inadequately sterilized instruments or theatre linen. An epidemiological survey was focused on the central sterilization unit of the hospital. The microbiological results of this survey proved that the cause of the outbreak was the use of inadequately decontaminated theatre linen. This study indicates that strict infection control measures including the control of sterilization procedures and a well-organized infection control team are necessary to prevent nosocomial surgical infections.


Subject(s)
Acinetobacter Infections/etiology , Bedding and Linens , Cross Infection/etiology , Intensive Care Units , Sepsis/etiology , Serratia Infections/etiology , Sterilization , Surgery Department, Hospital , Surgical Wound Infection/etiology , Adult , Cardiac Surgical Procedures , Equipment Contamination , Humans , Klebsiella Infections , Klebsiella pneumoniae , Male , Serratia marcescens , Ventriculoperitoneal Shunt
10.
Clin Microbiol Infect ; 7(10): 548-52, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11683795

ABSTRACT

OBJECTIVE: To determine the penicillin resistance and serotype distribution of Streptococcus pneumoniae strains and to identify clonal relationships of isolates resistant to penicillin by means of pulsed-field gel electrophoresis (PFGE). METHODS: In total, 193 S. pneumoniae strains were isolated from clinical specimens between November 1997 and January 2000. Susceptibility testing was carried out by E test, and serotyping by the Quellung reaction. Clonal relationship was analyzed by using PFGE with smaI endonuclease. RESULTS: Of the S. pneumoniae isolates, 23% were intermediately resistant to penicillin. There were no high-level resistant pneumococci. The majority of isolates intermediately resistant to penicillin were of serogroups/serotypes 19, 23, 14 and 1, in descending order of frequency. There were eight major clones in strains intermediately resistant to penicillin. It was seen that serogroups in the 23-valent polysaccharide vaccine, 7-valent, 9-valent, and 11-valent vaccine formulations caused 92%, 75%, 78% and 87% of pneumococcal diseases in our region, respectively. CONCLUSION: Penicillin resistance in S. pneumoniae is relatively uncommon in Kayseri. All vaccine formulations can prevent the majority of pneumococcal diseases, and there is genetic heterogeneity in intermediately penicillin-resistant pneumococci in this region.


Subject(s)
Penicillin G/pharmacology , Penicillin Resistance , Penicillins/pharmacology , Pneumococcal Infections/microbiology , Streptococcus pneumoniae/drug effects , Electrophoresis, Gel, Pulsed-Field , Humans , Microbial Sensitivity Tests , Pneumococcal Infections/drug therapy , Pneumococcal Infections/epidemiology , Serotyping , Streptococcus pneumoniae/classification , Streptococcus pneumoniae/isolation & purification , Turkey/epidemiology
11.
Clin Microbiol Infect ; 7(7): 369-72, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11531983

ABSTRACT

The objective of this study was to compare the performances of the standard aerobic bottle (StAe), FAN aerobic (FANAe) and enhanced FAN aerobic (E-FANAe) (the charcoal component of the FANAe was revised recently to improve the feasibility of Gram smear interpretation) blood culture bottles for BacT/Alert system for the detection of Brucella melitensis in simulated blood culture. Triplicate strains of eight clinical isolates of B. melitensis were studied. Each bottle was inoculated with 5 mL of freshly collected human blood at three different targeted bacterial inocula (10(1), 10(2) and 10(3) CFU/bottle). All bottles were monitored for up to 21 days or until they became positive. The results of time to detection (TTD) on the eight B. melitensis samples were as follows: at 10(1) CFU/bottle, the E-FANAe had a mean TTD significantly shorter than the StAe (48 h vs. 56.2 h, P < 0.05); and at 10(3) CFU/bottle, the FANAe and E-FANAe had a mean TTD significantly shorter than the StAe (41.2 h and 40 h vs. 45.6 h, P < 0.05). The reproducibilities (no.of positive signals/no.of all bottles) of three bottle systems were as follows: at 10(1) CFU/bottle, the reproducibilities of StAe, FANAe and E-FANAe were 96, 83 and 58%, respectively. At 10(3) CFU/bottle, the reproducibilities of StAe, FANAe and E-FANAe were 95, 95 and 91%, respectively. Positive results for the presence of bacteria in Gram smears were confirmed in 68% of StAe, 54% of FANAe and 90% of E-FANAe. In case of suspected brucellosis, the combination of one StAe bottle and one E-FANAe bottle seems to provide the highest and fastest recovery of the organism.


Subject(s)
Bacteremia/diagnosis , Brucella melitensis/isolation & purification , Brucellosis/diagnosis , Bacteremia/microbiology , Bacteriological Techniques , Brucella melitensis/growth & development , Brucellosis/microbiology , Colony Count, Microbial , Evaluation Studies as Topic , Humans , Reproducibility of Results
12.
J Chemother ; 13(5): 541-5, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11760219

ABSTRACT

Resistance of Streptococcus pneumoniae (750) to penicillin, erythromycin, chloramphenicol and trimethoprim/sulfamethoxazole isolated in 4 Turkish hospitals between 1996 and 1999 was evaluated according to year of isolation, patients' age groups and specimen. Penicillin susceptibility was determined by E-test strips and the other antibiotics were tested by disk diffusion test following the NCCLS guidelines in each center. Overall high and intermediate resistance to penicillin was 3% and 29%, respectively. There was a significant difference (p<0.001) between the centers with regard to penicillin resistance. However, there was no significant increase in resistance by year. Penicillin resistance varied significantly among children and adults (36% versus 25%) and according to the specimen. Highest rate of penicillin resistance was observed in respiratory specimens (36%) followed by ear exudates (33.5%). In blood isolates, resistance to penicillin was 28.6%. Overall resistance to erythromycin was 8%, to chloramphenicol 5% and to trimethoprim-sulfamethoxazole 47%. Although overall penicillin resistance in these Turkish S. pneumoniae isolates is high, resistance rates vary in each center and have not increased from 1996 to 1999.


Subject(s)
Anti-Bacterial Agents/pharmacology , Penicillin Resistance , Pneumococcal Infections/drug therapy , Streptococcus pneumoniae/drug effects , Adult , Child , Chloramphenicol/pharmacology , Drug Resistance , Erythromycin/pharmacology , Hospitals/statistics & numerical data , Humans , Incidence , Pneumococcal Infections/epidemiology , Pneumococcal Infections/pathology , Streptococcus pneumoniae/pathogenicity , Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology , Turkey/epidemiology
14.
Ophthalmic Res ; 32(2-3): 126-31, 2000.
Article in English | MEDLINE | ID: mdl-10754446

ABSTRACT

This study was designed to test the effects of intravitreal trovafloxacin on an experimental rabbit model of Staphylococcus epidermidis endophthalmitis. Out of 26 rabbits, 22 were given intravitreal S. epidermidis (100,000 CFU). At 24 h, group 1 (8 rabbits) and, at 48 h, group 2 (8 rabbits) received 100 microg intravitreal trovafloxacin. Group 3 (6 rabbits) was used as inoculated but untreated controls. Four rabbits (group 4) were used as uninfected controls. Clinical scores were calculated at 24, 48 and 72 h. Microbiological and histopathological scorings were made. Microbiological analysis showed that trovafloxacin administered at 24 or 48 h significantly reduced the number of bacteria compared to the untreated group. We conclude that trovafloxacin applied at 24 or 48 h is effective against S. epidermidis endophthalmitis in this experimental rabbit model.


Subject(s)
Anti-Infective Agents/therapeutic use , Endophthalmitis/drug therapy , Eye Infections, Bacterial/drug therapy , Fluoroquinolones , Naphthyridines/therapeutic use , Staphylococcal Infections/drug therapy , Staphylococcus epidermidis/drug effects , Animals , Anti-Infective Agents/administration & dosage , Colony Count, Microbial , Disease Models, Animal , Endophthalmitis/microbiology , Endophthalmitis/pathology , Eye Infections, Bacterial/microbiology , Eye Infections, Bacterial/pathology , Injections , Naphthyridines/administration & dosage , Rabbits , Staphylococcal Infections/microbiology , Staphylococcal Infections/pathology , Vitreous Body/drug effects
15.
J Antimicrob Chemother ; 43(3): 373-8, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10223593

ABSTRACT

This study was carried out with the participation of eight hospitals in Turkey to determine the frequency of gram-negative bacteria isolated in intensive care units (ICU) and to compare their resistance rates to selected antibiotics. Aerobic gram-negative bacteria isolated from ICUs during 1996 were studied. Antibiotic susceptibilities to imipenem, ceftazidime, ceftazidime-clavulanate, ceftriaxone, cefotaxime, cefepime, cefodizime, cefuroxime, piperacillin/tazobactam, amoxycillin-clavulanate, gentamicin, amikacin and ciprofloxacin were determined by Etest. A total of 748 isolates were obtained from 547 patients. The majority of organisms were isolated from the respiratory (38.8%) and urinary tracts (30.9%). Pseudomonas spp. were the most frequently isolated gram-negative species (26.8%), followed by Klebsiella spp. (26.2%). Escherichia coli, Acinetobacter spp. and Enterobacter spp. were the other commonly isolated organisms. High resistance rates were observed for all antibiotics studied. Imipenem appeared to be the most active agent against the majority of isolates. Although resistance rates exceeded 50%, ciprofloxacin, cefepime and amikacin were found to be relatively effective. Extended-spectrum beta-lactamase (ESBL) production appeared to be a major mechanism of resistance to beta-lactam antibiotics. In contrast to ceftazidime-clavulanate, piperacillin/tazobactam showed poor activity against organisms thought to produce ESBL, suggesting the presence of an enzyme resistant to tazobactam action. This study has yielded high rates of resistance in aerobic gram-negative isolates from ICUs in Turkey. High resistance rates to all the other antibacterials studied leave imipenem as the only reliable agent for the empirical treatment of ICU infections in Turkey.


Subject(s)
Drug Resistance, Microbial , Gram-Negative Bacteria/drug effects , Hospitals , Humans , Intensive Care Units , Microbial Sensitivity Tests , beta-Lactamases/physiology
17.
J Infect ; 36(1): 111-2, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9515679

ABSTRACT

A case is reported of a 43-year-old man who presented prostatitis and hepatitis due to Brucella melitensis. His symptoms were icterus, weakness, anorexia, fever, and urinary discomfort. Physical examination revealed icterus and hepatosplenomegaly. Lymphomonocytosis, elevated erythrocyte sedimentation rate and abnormal liver functions had been detected in laboratory tests. Brucella melitensis was isolated from prostatic fluid and blood cultures.


Subject(s)
Brucella melitensis/isolation & purification , Brucellosis/complications , Hepatitis/microbiology , Prostatitis/microbiology , Adult , Brucella melitensis/pathogenicity , Brucellosis/diagnostic imaging , Hepatitis/diagnostic imaging , Humans , Male , Prostatitis/diagnostic imaging , Ultrasonography
18.
Turk J Pediatr ; 38(2): 183-8, 1996.
Article in English | MEDLINE | ID: mdl-8701482

ABSTRACT

Drug resistance patterns of 68 shigella strains were investigated prospectively in Kayseri during a period of approximately two years. The resistance was highest with ampicillin (58.8%) followed by co-trimoxazole (50%) and ampicillin-sulbactam (13%). Only 2.8 percent of cases were resistant to gentamicin, and all serogroups were sensitive to ceftriaxone. We conclude that in children with severe shigellosis, treatment with ceftriaxone is effective and better than ampicillin and co-trimoxazole for obtaining a clinical cure. We followed 18 children who experienced convulsions associated with shigellosis. Only one child had a history of febrile convulsions, and two children had histories of convulsive disorders. The majority of the children had generalized, self-limited convulsions which lasted less than ten minutes. Due to the benign and self-limited nature of most of the convulsions, neither diagnostic procedures nor drug therapy are usually necessary. These measures should, however, be considered in complicated cases characterized by focal or prolonged seizures.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Dysentery, Bacillary/complications , Seizures/etiology , Shigella flexneri/drug effects , Shigella sonnei/drug effects , Adolescent , Anti-Bacterial Agents/pharmacology , Child , Child, Preschool , Drug Resistance, Microbial , Drug Therapy, Combination/pharmacology , Drug Therapy, Combination/therapeutic use , Dysentery, Bacillary/drug therapy , Dysentery, Bacillary/microbiology , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Prospective Studies , Seizures/diagnosis , Shigella/drug effects , Shigella/isolation & purification , Shigella flexneri/isolation & purification , Shigella sonnei/isolation & purification , Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
19.
Mikrobiyol Bul ; 27(1): 36-41, 1993 Jan.
Article in Turkish | MEDLINE | ID: mdl-8421441

ABSTRACT

Eighteen patients with epididymo-orchitis were reviewed clinically, microbiologically and serologically. While there were positive urine culture in 5 patients before treatment, only one of them had positive culture in the epididymal aspirate. The epididymo-orchitis in two patients was the complications of the brucellosis. Ofloxacin or doxycycline was used in the treatment of 16 patients for 2-3 weeks and all, except one patient were recovered completely. The cases secondary to the brucellosis were treated with rifampicin plus doxycycline combination for 6 weeks. After treatment, no positive urine cultures were noted in all patients. As a result the epididymal aspiration to clarify etiological agent is not necessarily needed and empirical treatment may be generally curative.


Subject(s)
Epididymitis , Orchitis , Adolescent , Adult , Bacteriuria/microbiology , Brucellosis/complications , Doxycycline/therapeutic use , Drug Therapy, Combination , Epididymitis/drug therapy , Epididymitis/etiology , Epididymitis/microbiology , Escherichia coli/isolation & purification , Escherichia coli Infections/drug therapy , Escherichia coli Infections/microbiology , Humans , Male , Middle Aged , Ofloxacin/therapeutic use , Orchitis/drug therapy , Orchitis/etiology , Orchitis/microbiology , Prospective Studies , Rifampin/therapeutic use
SELECTION OF CITATIONS
SEARCH DETAIL
...