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J Biomol Struct Dyn ; 37(10): 2695-2702, 2019 Jul.
Article in English | MEDLINE | ID: mdl-30052139

ABSTRACT

Gene PA4980 from Pseudomonas aeruginosa encodes a putative enoyl-coenzyme A hydratase/isomerase that is associated with the function of the biofilm dispersion-inducing signal molecule cis-2-decenoic acid. To elucidate the role of PA4980 in cis-2-decenoic acid biosynthesis, we reported the crystal structure of its protein product at 2.39 Å. The structural analysis and substrate binding prediction suggest that it acts as a monofunctional enoyl-coenzyme A isomerase, implicating an alternative pathway of the cis-2-decenoic acid synthesis.


Subject(s)
Dodecenoyl-CoA Isomerase/chemistry , Models, Molecular , Protein Conformation , Pseudomonas aeruginosa/enzymology , Amino Acid Sequence , Dodecenoyl-CoA Isomerase/metabolism , Fatty Acids, Unsaturated/chemistry , Fatty Acids, Unsaturated/metabolism , Isomerases/chemistry , Isomerases/metabolism , Lipid Metabolism , Molecular Dynamics Simulation , Protein Array Analysis , Protein Binding , Structure-Activity Relationship
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