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Clin Exp Med ; 24(1): 128, 2024 Jun 17.
Article in English | MEDLINE | ID: mdl-38884843

ABSTRACT

CD8 + T cells exert a critical role in eliminating cancers and chronic infections, and can provide long-term protective immunity. However, under the exposure of persistent antigen, CD8 + T cells can differentiate into terminally exhausted CD8 + T cells and lose the ability of immune surveillance and disease clearance. New insights into the molecular mechanisms of T-cell exhaustion suggest that it is a potential way to improve the efficacy of immunotherapy by restoring the function of exhausted CD8 + T cells. Transforming growth factor-ß (TGF-ß) is an important executor of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Recent studies have shown that TGF-ß is one of the drivers for the development of exhausted CD8 + T cells. In this review, we summarized the role and mechanisms of TGF-ß in the formation of exhausted CD8 + T cells and discussed ways to target those to ultimately enhance the efficacy of immunotherapy.


Subject(s)
CD8-Positive T-Lymphocytes , Transforming Growth Factor beta , Humans , Transforming Growth Factor beta/metabolism , CD8-Positive T-Lymphocytes/immunology , Immunotherapy/methods , Neoplasms/immunology , Neoplasms/therapy , Animals
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