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PLoS One ; 15(11): e0236203, 2020.
Article in English | MEDLINE | ID: mdl-33175875

ABSTRACT

BACKGROUND/AIM: To use liquid chromatography-mass spectrometry (LC-MS) to identify endogenous differential metabolites in the urine of rats with chronic atrophic gastritis (CAG). MATERIALS AND METHODS: Methylnitronitrosoguanidine (MNNG) was used to produce a CAG model in Wistar rats, and HE staining was used to determine the pathological model. LC-MS was used to detect the differential metabolic profiles in rat urine. Diversified analysis was performed by the statistical method. RESULTS: Compared with the control group, the model group had 68 differential metabolites, 25 that were upregulated and 43 that were downregulated. The main metabolic pathways were D-glutamine and D-glutamic acid metabolism, histidine metabolism and purine metabolism. CONCLUSION: By searching for differential metabolites and metabolic pathways in the urine of CAG rats, this study provides effective experimental data for the pathogenesis and clinical diagnosis of CAG.


Subject(s)
Biomarkers/urine , Disease Models, Animal , Gastritis, Atrophic/pathology , Gastritis, Atrophic/urine , Metabolic Networks and Pathways , Metabolomics/methods , Animals , Male , Rats , Rats, Wistar
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