ABSTRACT
Ultrasound-promoted synthesis of bis(indolyl)methanes catalyzed by ABS via the reaction of indole or N-methylindole with aromatic aldehyde was carried out in excellent yields in aqueous media at 23-25°C, providing a simple and efficient synthesis of these compounds.
Subject(s)
Benzenesulfonates/chemistry , Indoles/chemical synthesis , Ultrasonics , Catalysis , Indoles/chemistry , Water/chemistryABSTRACT
Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69-98% yields in acetic acid aqueous solution at 35°C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.
Subject(s)
Acetates/chemistry , Indoles/chemical synthesis , Ultrasonics , Amines/chemistry , Formaldehyde/chemistry , Indoles/chemistry , Solutions , Water/chemistryABSTRACT
A convenient and efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation at room temperature has been described. In comparison to two-step methods, the present procedure has the advantages of mild conditions, shorter reaction time, without isolation of any intermediate, saves energy and no requirement of toxic solvent.
Subject(s)
Acetophenones/chemistry , Aldehydes/chemistry , Epoxy Compounds/chemical synthesis , Propane/chemical synthesis , Ultrasonics , Benzaldehydes/chemistry , Chemistry, Organic/methods , Hydroxides/chemistry , Magnetic Resonance Spectroscopy , Models, Chemical , Potassium Compounds/chemistry , Solvents/chemistry , Temperature , Time FactorsABSTRACT
An efficient synthesis of 3-aryl-3-hydroxy-2-(1H-indol-3-yl)-1-phenyl-1-propanone via the cleavage of epoxides with indole promoted by ultrasound irradiation was carried out in good yields by using montmorillonite K10-ZnCl(2) within 2-5h at room temperature. This method provides several advantages such as operational simplicity, high yield and mild conditions.
Subject(s)
Chemistry, Organic/methods , Epoxy Compounds/chemistry , Indoles/chemistry , Ultrasonics , Bentonite/chemistry , Catalysis , Chlorides/chemistry , Magnetic Resonance Spectroscopy , Models, Chemical , Temperature , Time Factors , Zinc Compounds/chemistryABSTRACT
The synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions of 3-aryl-2,3-epoxy-1-phenyl-1-propanone with phenylhydrazine was carried out in 69-99% yields at room temperature under ultrasound irradiation. This method provides several advantages such as operational simplicity, higher yield and environment friendly.
Subject(s)
Hydrochloric Acid/chemistry , Phenylhydrazines/chemistry , Phenylhydrazines/radiation effects , Propane/chemistry , Propane/radiation effects , Pyrazoles/chemical synthesis , Pyrazoles/radiation effects , Sonication/methods , Catalysis , Hydrochloric Acid/radiation effects , Radiation DosageABSTRACT
Deprotection of oximes to the corresponding carbonyl compounds in silica sulfuric acid/surfactant/paraformaldehyde system can be carried out in excellent yields at 50 degrees C in water under ultrasound irradiation.
Subject(s)
Carbon/chemistry , Carbon/radiation effects , Oximes/chemistry , Oximes/radiation effects , Silicon Dioxide/chemistry , Sonication/methods , Sulfuric Acids/chemistry , Sulfuric Acids/radiation effects , Catalysis , Formaldehyde/chemistry , Formaldehyde/radiation effects , Polymers/chemistry , Polymers/radiation effects , Solutions/chemistry , Surface-Active Agents/chemistry , Surface-Active Agents/radiation effects , Water/chemistryABSTRACT
Synthesis of the glycolurils catalyzed by potassium hydroxide was carried out in 17-75% yield at 40 degrees C in EtOH under ultrasound irradiation. Compared to the method using stirring, the main advantage of the present procedure is milder conditions and shorter reaction time.
