Iron-Catalyzed Aminoalkylative Carbonylative Cyclization of Alkenes toward α-Tetralones.

Carbonylative multifunctionalization of alkenes is an efficient approach to introduce multiple functional groups into one molecule from easily available materials. Herein, we developed an iron-catalyzed radical relay carbonylative cyclization of alkenes with acetamides. Various α-tetralones can be constructed in moderate yields from readily available substrates with an earth-abundant iron salt as the catalyst.

Cobalt-Catalyzed Carbonylative Synthesis of 4-Oxobutanoates from Formamide and Ethylene.

The direct concurrent installation of amide and ester groups across olefin motifs represents a powerful and promising functionalization tool in organic chemistry. Herein, a ligand-free cobalt-catalyzed four-component radical relay carbonylative difunctionalization of ethylene for the synthesis of 4-oxobutanoates has been developed. Valuable C4 building blocks were produced in a highly atom-economical fashion.

Cobalt-Catalyzed Hydroxymethylation of Alkyl Halides with CO as the C1 Source.

Herein, we developed an effective strategy for the synthesis of one-carbon-extended alcohols through cobalt-catalyzed hydroxymethylation of alkyl halides with carbon monoxide as the C1 source and cheap and environmentally friendly PMHS as the hydride source. This procedure also features a ligand-free cobalt catalyst and a broad range of functional group tolerance.