Novel Reinforcing Techniques and Bearing Capacity Analysis for Tunnel Lining Structures with Extensive Corrosion.

Affected by the erosive environment, tunnel lining concrete in the long-term service zprocess often exhibits engineering diseases such as concrete corrosion degradation and loss of strength, decreasing the stability of the tunnel lining structure and the traffic safety. Based on HTG tunnel project, the basic distribution rule of tunnel lining corrosion and macro mechanical properties of corroded concrete were explored in this paper through engineering disease site investigation. Then, on this basis, aiming at large-scale corrosion of tunnel lining structure, two reinforcement and repair schemes are proposed, corrugated steel plate reinforcement method and channel steel reinforcement method. Indoor component tests are carried out on the two reinforcement schemes. The failure characteristics and stress and deformation law of tunnel lining members after reinforcement and repair were verified. The analysis showed that the failure process of the reinforced specimens on the tensile side could be divided into the non-cracking stage and the working stage with cracks, and the cracking load and failure load of the specimens were significantly increased. The bearing capacity of the reinforced specimens was divided into the ultimate bearing capacity against cracking and the ultimate bearing capacity during failure. Finally, the calculation methods of the bearing capacity of the channel steel reinforcement method and the corrugated steel plate reinforcement method were derived. Comparative analysis shows that the results of numerical simulation, experimental testing and theoretical simplification methods are close to each other, and the maximum deviation is less than 8%. The established method for calculating the bearing capacity of corroded components after reinforcement is reliable and can be used for the design calculation of corroded lining reinforcement.

[Research Progress of Pharmacological Therapy and Nutritional Support for Cachexia 
in Lung Cancer Patients].

Cachexia is a common complication in patients with lung cancer. It aggravates the toxic and side effects of chemotherapy, hinders the treatment plan, weakens the responsiveness of chemotherapy, reduces the quality of life, increases complications and mortality, and seriously endangers the physical and mental health of patients with lung cancer. The causes and pathogenesis of tumor cachexia are extremely complex, which makes its treatment difficult and complex. Controlling cachexia in lung cancer patients requires many means such as anti-tumor therapy, inhibition of inflammatory response, nutritional support, physical exercise, and relief of symptoms to exert the synergistic effect of multimodal therapy against multiple mechanisms of tumor cachexia. To date, there has been a consensus within the discipline that no single therapy can control the development of cachexia. Some therapies have made some progress, but they need to be implemented in combination with multimodal therapy after fully assessing the individual characteristics of lung cancer patients. This article reviews the application of drug therapy and nutritional support in lung cancer patients, and looks forward to the research direction of cachexia control in lung cancer patients.
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MiR-379-5p inhibits the proliferation, migration, and invasion of breast cancer by targeting KIF4A.

BACKGROUND: Many studies have shown that microRNAs (miRNAs) play an essential role in gene regulation and tumor development. This study aimed to explore the expression of miR-379-5p and its mechanisms of affecting proliferation, migration, and invasion in breast cancer (BC). METHODS: MiRNAs and mRNAs expression data of BC and normal breast tissue samples were downloaded from the TCGA and GEO databases. qRT-PCR was used to detect the expression of miR-379-5p in human normal breast epithelial cell lines and human BC cell lines. The proliferation ability of transfected cells was detected by colony formation and EdU assays. The mobility and invasion ability of transfected cells was measured by wound healing and transwell assays. The relative protein expression of transfected cells was detected by western blot. Dual luciferase reporter assay was performed to identify the targeted binding of miR-379-5p and KIF4A. RESULTS: MiR-379-5p was lowly expressed in BC tissue samples and BC cell lines. The target genes of miR-379-5p were involved in many cancer-related signaling pathways. PPI analysis and the cytoHubba algorithm of Cytoscape identified 10 genes as the hub genes. Survival analysis showed that only KIF4A expression in 10 hub genes was significantly associated with the prognosis of BC patients and was significantly upregulated in BC. Overexpression of miR-379-5p inhibited proliferation, migration, and invasion in the BC cell line MDA-MB-231, which could be reversed by KIF4A. CONCLUSIONS: MiR-379-5p inhibits proliferation, migration, and invasion of BC by targeting KIF4A.