ABSTRACT
To investigate the clinical efficacy of antibiotic impregnated beads on the tibial chronic osteomyelitis, so as to search for a more applicable method for the treatment. Through comparative analysis, we divided 72 patients with chronic tibial osteomyelitis who received treatment in hospital between January 2016 and December 2016 randomly into two groups: Control group (n=36) and the experiment group (n=36). Patients in the control group underwent closed lavage plus drainage for treatment, while those in the experiment group received the antibiotic impregnated beads. After treatment, we compared the times of treatment, average length of stay in hospital and the efficacy between two groups, and data were analyzed using SPSS 15.0 software. In the control group, average length of stay in hospital was ((3.3±0.9) months, average time of surgery was (2.9±1.8) times, cure rate was 25.0% and elimination rate of bacteria was 88.0%; in the experiment group, average length of stay in hospital was ((2.2±1.3) months, average time of surgery was (2.4±1.0) times, cure rate was 47.2%, and elimination rate of bacteria was 93.8%. Differences in the average length of stay in hospital, the cure rate and elimination rate of bacteria between two groups showed statistical significance (p<0.05). For tibial chronic osteomyelitis, antibiotic impregnated bead implantation can reduce the chance of secondary infection after operation and shorten the hospitalization time, showing a more promising effect than the closed lavage and drainage, and this method is worthy of being promoted in clinical practice.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Microspheres , Osteomyelitis/drug therapy , Adolescent , Adult , Child , Chronic Disease/drug therapy , Drainage , Drug Carriers/therapeutic use , Female , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Operative Time , Osteomyelitis/microbiology , Osteomyelitis/surgery , Therapeutic Irrigation , Tibia/drug effects , Treatment Outcome , Young AdultABSTRACT
The study was to evaluate the contribution of connective tissue growth factor (CTGF) to the regeneration of the torn anterior cruciate ligament (ACL) in a rabbit. ACL transection surgeries were performed on both knees of male New Zealand rabbits. Then injury reparation was done as follows: 0.5ml fibrin glue (FG) alone (FG-treated group, n=24 knees) and 0.5ml FG dissolve with 15ng CTGF (CTGF/FG-treated group, n=24 knees). At 2 or 6 weeks after surgery, the ACLs were characterized histologically (n=6 knees) and biomechanically (n=6 knees). The healing effect of the CTGF/FG-treated group was obviously better than that of the FG-treated group, with an increased amount of collagen fibers and fibroblasts in the ligament tissue. After 2 or 6 weeks of healing, CTGF/FG-treated group exhibited significantly higher maximum loads of 8.50±0.58N and 16.35±1.16N, compared with the control group (7.52±0.80N and 13.60±1.35N). And the stiffness of CTGF/FG-treated group at 2 or 6 weeks post-intervention (5.59±1.24N/mm and 11.64±2.21N/mm) was remarkably higher than that the control group (3.74±0.89N/mm and 6.83±2.51N/mm). CTGF could serve as a potentially attractive tool for improving ACL injury treatment by promoting the regeneration of related cells.
