1.
Ultrason Sonochem
; 18(1): 42-4, 2011 Jan.
Article
in English
| MEDLINE
| ID: mdl-20646952
ABSTRACT
Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69-98% yields in acetic acid aqueous solution at 35°C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.