Multi-color complex spatial light modulation with a single digital micromirror device.

Spatial light modulators enabling complex light field manipulation has opened up many opportunities in biomedical imaging, holographic display, and adaptive optics. However, traditional spatial light modulators do not allow multi-color operations simultaneously due to their physical constraints, while multi-color modulations are highly desirable in many applications. To overcome this limitation, we demonstrate a multi-color spatial complex light field modulation with a single binary hologram on digital micromirror devices (DMD). This method combines several neighboring micro-mirror pixels into a giant single superpixel, in which the light field's amplitude and phase can be individually determined by internal pixel combinations, and the dynamic range of phase modulation can exceed 2π for the single wavelength. As a result, this extra phase modulation range offers an additional degree of freedom for independent multi-wavelength light modulation. Based on this scheme, multi-color light modulations have been demonstrated in a 2D plane as well as in multiple 3D holographic planes. Moreover, a dual-colored Airy beam has been realized using the same technique. These results bring complex light modulation into a multi-color regime, paving the way for practical applications in information display, imaging, and optical trapping.

Experimental study on remediation of low permeability Cu-Zn contaminated clay by vacuum enhanced leaching combined with EDTA and hydrochloric acid.

To improve the washing efficiency for low permeable clay, the method of vacuum enhanced washing technology was proposed. In this study, ethylene diamine tetraacetic acid (EDTA) and hydrochloric acid (HCl) as eluents, the experiments of remediation of Cu-Zn contaminated cohesive soil by traditional soil column leaching and vacuum enhanced leaching was carried out. Results show that compared with traditional leaching method, the vacuum enhanced leaching method can significantly shorten the leaching time and prominently improve the removal rate of heavy metals Cu-Zn. When concentration of EDTA is 0.1 mol/L, the removal rate of Cu-Zn can reach 95.7% and 82.9%, respectively by vacuum-enhanced leaching. When concentration of HCl is 0.2 mol/L, the removal rate of Cu-Zn by vacuum enhanced leaching method can reach 96.2% and 90.2%, respectively. Whereas, the higher the concentration of EDTA and HCl, the slower the leaching rate. At the same concentration, the leaching rate of HCl was faster. After HCl leaching, the soil structure was seriously corroded, and the relative content of mineral composition changed considerably. After EDTA leaching, the corrosion of soil structure is light, and the relative content of mineral composition changes little. The conclusions obtained are of crucial theoretical value and technical support for environmental engineering.

Changes in plasma HDL and its subcomponents HDL2b and HDL3 regulate inflammatory response by modulating SOCS1 signaling to affect severity degree and prognosis of sepsis.

OBJECTIVES: To explore if SOCS1 is regulated by plasma HDL and its subcomponents HDL2b and HDL3 to affect inflammatory reaction then to influence the severity degree and prognosis of sepsis. METHODS: One hundred sepsis patients in ICU and 85 normal control persons from October 2018 to October 2019 in our hospital were enrolled. Adult male C57BL/6 mice were used to establish sepsis model by CLP method. HDL, CRP, and WBC count of human were measured using an auto-analyzer. Plasma HDL, IL-1ß, and TNF-α proteins levels of mice were measured with ELISA. Microfluidic chip was used for plasma HDL2b and HDL3 detections. SOCS1 in liver and spleen of mice were measured by qRT-PCR. The relationship between plasma HDL//HDL2b and inflammatory indices/SOCS1 in liver/spleen was analyzed with spearman correlation coefficient method. The sepsis patients/mice were divided into non-survival and survival groups. The sepsis patients were divided into severe and mild sepsis patients based on the SOFA score or divided into high and low score groups according to the APACHE II score. The sepsis mice were divided into high and low score group based on the modified sepsis severity score criterion. RESULTS: Plasma HDL and HDL2b levels were significantly declined (P < 0.01), while HDL3 was normal in both sepsis patients and mice (P > 0.05). Plasma HDL and HDL2b were negatively associated with the serum CRP concentration and positively correlated with the prognosis and severity in sepsis patients (P < 0.05). Moreover, the downregulated plasma HDL but not HDL2b was negatively related to increased SOCS1 mRNA levels in liver and spleen of mice, which were positively connected with TNF-α and IL-1ß protein levels (P < 0.05). CONCLUSIONS: Plasma HDL is downregulated in sepsis, which may facilitate inflammatory reaction then activate the SOCS1 signaling to regulate the severity and affect prognosis of sepsis. The decline of plasma HDL2b content could aggravate the severity and poor prognosis of sepsis through facilitating inflammatory reaction. The plasma HDL3 is not involved in sepsis. The more and further explorations may be needed.