Subject(s)
Pregnancy Complications, Infectious , Tuberculosis, Cutaneous/complications , Tuberculosis, Ocular/complications , Antitubercular Agents/therapeutic use , Female , Humans , Infant, Newborn , Live Birth , Pregnancy , Pregnancy Complications, Infectious/drug therapy , Tuberculosis, Cutaneous/drug therapy , Tuberculosis, Ocular/drug therapy , Young AdultABSTRACT
OBJECTIVE: To report a case of triploidy in a women who conceived after intracytoplasmic sperm injection (ICSI). DESIGN: Case report. SETTING: Maternity unit of a university hospital. PATIENT(S): A 29-year-old woman who was pregnant following intracytoplasmic sperm injection (ICSI). INTERVENTION(S): Ultrasound and serum screening. MAIN OUTCOME MEASURE(S): Amniocentesis and postmortem findings. RESULT(S): Amniocentesis confirmed the karyotype to be 69XXY, and the pregnancy was terminated. CONCLUSION(S): This case refers to diandric triploidy resulting from fertilization by diploid sperm.
Subject(s)
Chromosome Aberrations , Hydatidiform Mole/etiology , Sperm Injections, Intracytoplasmic , Spermatozoa/abnormalities , Adult , Diploidy , Female , Humans , Hydatidiform Mole/genetics , Male , Polyploidy , PregnancyABSTRACT
Pre-eclampsia is a multisystem disorder of pregnancy usually associated with raised blood pressure (BP) and proteinuria. The pathogenesis is not understood despite decades of research. Abnormal placentation related to immune mechanisms and maladaptation of the placenta may be the first step in the development of the disease. Although there are a number of risk factors and new innovatory tests (e.g., uterine artery Doppler) which can be used to predict pre-eclampsia, none fulfils standard diagnostic criteria. Of possible prophylactic value are antiplatelet agents, calcium supplementation and vitamins C and E. Prevention of eclampsia with magnesium sulfate is the subject of a current international randomised controlled trial (RCT), known as MAGPIE. Therapeutic strategies include avoidance of hypertensive injury and delivery of the baby and placenta. Further research into specific antihypertensive agents and conservative management strategies is required.
