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1.
J Assoc Physicians India ; 56: 719-20, 2008 Sep.
Article in English | MEDLINE | ID: mdl-19086362

ABSTRACT

A 59-year-old lady presented with hypertensive hemorrhage involving the pons. Since she presented within 3 hours of onset of the stroke, recombinant factor VIIa was administered. From a state of altered sensorium there was a rapid recovery of consciousness followed by gradual improvement in limb weakness. Serial CT scans of the brain revealed no further expansion of the hematoma. The hematoma progressively resolved. Recombinant factor VIIa could be an attractive therapeutic option in treating hemorrhages at critical sites like brainstem where expansion of hematoma could be fatal.


Subject(s)
Factor VIIa/therapeutic use , Intracranial Hemorrhage, Hypertensive/drug therapy , Female , Hematoma/drug therapy , Humans , Middle Aged , Recombinant Proteins/therapeutic use
2.
J Assoc Physicians India ; 53: 642-4, 2005 Jul.
Article in English | MEDLINE | ID: mdl-16190136

ABSTRACT

A patient who presented with recurrent venous thrombosis is reported. Following an episode of spontaneous deep vein thrombosis of the lower limb he was started on oral anticoagulant therapy, which he discontinued. He presented with cerebral venous thrombosis and improved partially with anticoagulant therapy. Evaluation for hypercoagulable states revealed factor V Leiden mutation by polymerized chain reaction method. Long-term anticoagulation has been planned. Evaluation for factor V Leiden mutation is always warranted in patients presenting with spontaneous thrombosis, especially if there is recurrent thrombosis.


Subject(s)
Factor V/genetics , Mutation , Venous Thrombosis/drug therapy , Adult , Anticoagulants/administration & dosage , Anticoagulants/therapeutic use , Humans , Male , Recurrence , Venous Thrombosis/genetics , Venous Thrombosis/pathology
3.
J Neurol Sci ; 225(1-2): 161-4, 2004 Oct 15.
Article in English | MEDLINE | ID: mdl-15465102

ABSTRACT

A patient who developed neurological and renal complications following coronary angiogram and coronary artery bypass grafting is reported. Neurological involvement was in the form of fluctuating sensorium and a subcortical pattern of dementia. Renal failure was seen in the form of raised urea and creatinine levels. Renal biopsy revealed the cause of the renal failure to be due to cholesterol embolic disease. While the sensorium often improved following renal replacement therapy (dialysis), the dementia was poorly responsive to therapy. The patient succumbed due to progressive renal failure. Awareness of the protean manifestations and a high index of suspicion are essential for appropriate diagnosis in order to enable the clinician to accurately prognosticate in this often fatal disease.


Subject(s)
Cognition Disorders/etiology , Embolism, Cholesterol/complications , Basal Ganglia/pathology , Coronary Artery Bypass/adverse effects , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Postoperative Complications , Renal Artery/pathology , Renal Dialysis/methods , Thalamus/pathology
4.
J Neurol Sci ; 219(1-2): 163-6, 2004 Apr 15.
Article in English | MEDLINE | ID: mdl-15050453

ABSTRACT

A patient with the typical features of neuroacanthocytosis is reported. Chorea, tics, personality changes and caudate atrophy on cranial MRI resulted in an erroneous diagnosis of Huntington's disease elsewhere. Attention to other features viz., absence of ocular motility disturbances, amyotrophy, areflexia, EMG evidence of axonopathy, raised serum creatinine phosphokinase (CPK) levels and the typical erythrocytic acanthocytosis enabled us to establish the correct diagnosis. The typical features of the disease as seen in the patient are discussed. In view of the implications for genetic counseling, careful clinical and laboratory evaluation is always warranted to exclude neuroacanthocytosis in all suspected cases of Huntington's disease.


Subject(s)
Chorea/diagnosis , Diagnostic Errors , Huntington Disease/diagnosis , Adult , Atrophy , Caudate Nucleus/pathology , Deglutition Disorders/diagnosis , Diagnosis, Differential , Humans , Magnetic Resonance Imaging , Male
5.
Clin Neurophysiol ; 114(12): 2334-7, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14652092

ABSTRACT

OBJECTIVE: Prevalence of Martin-Gruber anastomosis, an anomalous median-to-ulnar forearm communication, is well reported in literature while Marinacci communication, the reverse of Martin-Gruber with a forearm ulnar-to-median communication is under-recognized. We systematically evaluated the presence of Marinacci communication in a series of patients referred for electrophysiological studies. METHODS: One hundred consecutive patients referred to the electrophysiological laboratory for various diagnoses were studied using standard techniques for motor, sensory and f wave studies. RESULTS: Of the 100 patients (200 arms) studied, electrophysiological features of Marinacci communication were observed in 4 patients (7 arms). Median stimulation with recording over abductor pollicis brevis (APB) revealed a pseudo-conduction block over the forearm segment while on ulnar stimulation and recording over abductor digiti minimi (ADM), the amplitude of the compound muscle action potential (CMAP) obtained on proximal stimulation was higher than that obtained on distal stimulation. Ulnar stimulation at the elbow but not at the wrist revealed CMAP from APB without initial positivity. Its amplitude was 50% of the amplitude obtained on median stimulation at the wrist. CONCLUSIONS: Marinacci communication is not uncommon in the general population. A pseudo-conduction block on median stimulation and higher CMAP amplitude on proximal than distal stimulation provide valuable clues to its recognition.


Subject(s)
Median Nerve/abnormalities , Peripheral Nervous System Diseases/pathology , Peripheral Nervous System Diseases/physiopathology , Ulnar Nerve/abnormalities , Action Potentials , Electrophysiology , Humans , Median Nerve/physiopathology , Neural Conduction , Peripheral Nervous System Diseases/epidemiology , Prevalence , Prospective Studies , Ulnar Nerve/physiopathology
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