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1.
Am J Obstet Gynecol ; 210(2): 136.e1-6, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24055586

ABSTRACT

OBJECTIVE: When uterotonics fail to cause sustained uterine contractions and satisfactory control of hemorrhage after delivery, tamponade of the uterus can be effective in decreasing hemorrhage secondary to uterine atony. STUDY DESIGN: These data are from a postmarketing surveillance study of a novel dual-balloon catheter tamponade device, the Belfort-Dildy Obstetrical Tamponade System (ebb). RESULTS: A total of 57 women were enrolled: 55 women had the diagnosis of postpartum hemorrhage, and 51 women had uterine balloon placement within the uterine cavity. This study reports the outcomes in the 51 women who had uterine balloon placement within the uterine cavity for treatment of postpartum hemorrhage, as defined by the "Instructions for Use." We further assessed 4 subgroups: uterine atony only (n = 28 women), placentation abnormalities (n = 8 women), both uterine atony and placentation abnormalities (n = 9 women), and neither uterine atony nor placentation abnormalities (n = 6 women). The median (range) time interval between delivery and balloon placement was 2.2 hours (0.3-210 hours) for the entire cohort (n = 51 women) and 1.3 hours (0.5-7.0 hours) for the uterine atony only group (n = 28 women). Bleeding decreased in 22/51 of cases (43%), stopped in 28/51 of cases (55%), thus decreased or stopped in 50/51 of the cases (98%) after balloon placement. Nearly one-half (23/51) of all women required uterine balloon volumes of >500 mL to control bleeding. CONCLUSION: We conclude that uterine/vaginal balloon tamponade is very useful in the management of postpartum hemorrhage because of uterine atony and abnormal placentation.


Subject(s)
Postpartum Hemorrhage/therapy , Uterine Balloon Tamponade/instrumentation , Adult , Delivery, Obstetric , Female , Humans , Middle Aged , Placenta/abnormalities , Postpartum Hemorrhage/etiology , Pregnancy , Treatment Outcome , Uterine Inertia/therapy
2.
J Vasc Surg ; 59(2): 456-64, 2014 Feb.
Article in English | MEDLINE | ID: mdl-23958068

ABSTRACT

BACKGROUND: Extensive deep venous thrombosis (DVT) during pregnancy is usually treated with anticoagulation alone, risking significant post-thrombotic syndrome (PTS) in young patients. Catheter-directed thrombolysis (CDT) and operative venous thrombectomy have been safely and effectively used in nonpregnant patients, demonstrating significant reduction in post-thrombotic morbidity. This report reviews short- and long-term outcomes of 13 patients with extensive DVT of pregnancy treated with a strategy of thrombus removal. METHODS: From 1999 to 2013, 13 patients with iliofemoral DVT during pregnancy were offered CDT, pharmacomechanical thrombolysis (PMT), and/or venous thrombectomy. Gestational age ranged from 8 to 34 weeks. Fetal monitoring was performed throughout hospitalization. Radiation exposure was minimized with pelvic lead shields, focal fluoroscopy, and limited angiographic runs. Follow-up included objective vein evaluation using venous duplex and PTS assessment using the Villalta scale. RESULTS: CDT and/or PMT were used in 11 patients. Two patients underwent venous thrombectomy alone, and one patient had operative thrombectomy as an adjunct to CDT and PMT. Each patient had complete or near-complete thrombus resolution and rapid improvement in clinical symptoms. Eight of 11 having CDT or PMT underwent venoplasty and stenting of the involved iliac veins. Twelve of the 13 delivered healthy infants at term. One patient opted for termination of her pregnancy. Mean patient and gestational ages were 26 years and 26 weeks, respectively. Mean follow-up was 1.3 years, with only one recurrence. Duplex ultrasonography demonstrated patent veins in all but one patient and normal valve function in 10 patients. Eleven patients had Villalta scores <5 (considered normal), with a mean score of 0.7. CONCLUSIONS: Extensive DVT of pregnancy can be effectively and safely treated with a strategy of thrombus removal, resulting in a patent venous system, normal valve function in many, prevention of PTS, and reduction in recurrence.


Subject(s)
Femoral Vein/surgery , Iliac Vein/surgery , Pregnancy Complications, Cardiovascular/therapy , Thrombectomy , Thrombolytic Therapy , Venous Thrombosis/therapy , Adult , Female , Femoral Vein/diagnostic imaging , Femoral Vein/physiopathology , Gestational Age , Humans , Iliac Vein/diagnostic imaging , Iliac Vein/physiopathology , Phlebography , Postthrombotic Syndrome/prevention & control , Pregnancy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/physiopathology , Retrospective Studies , Secondary Prevention , Time Factors , Treatment Outcome , Ultrasonography, Doppler, Duplex , Vascular Patency , Venous Thrombosis/diagnosis , Venous Thrombosis/physiopathology
3.
Hypertens Pregnancy ; 30(1): 18-27, 2011.
Article in English | MEDLINE | ID: mdl-20482334

ABSTRACT

OBJECTIVE: To compare the performance of prototype Access® sVEGF R1 and PlGF automated immunoassays from Beckman Coulter to the Quantikine® microplate ELISA assays by R&D Systems. METHODS: Samples obtained from pregnant women, non-pregnant women and men were assayed according to manufacturers' instructions. RESULTS: Compared to the Quantikine assays, the Access assays demonstrated improved precision, increased sensitivity, broader dynamic ranges, and reduced analysis time. The Access assays were found to be specific for free sVEGF R1 and free PlGF. CONCLUSION: There was good correlation between the Access and Quantikine assays. Superior performance by Access assays may have important prenatal diagnostic implications.


Subject(s)
Immunoassay/methods , Pregnancy Proteins/blood , Vascular Endothelial Growth Factor Receptor-1/blood , Adult , Female , Humans , Male , Placenta Growth Factor , Pre-Eclampsia/blood , Pre-Eclampsia/diagnosis , Pregnancy , Sensitivity and Specificity
4.
Am J Obstet Gynecol ; 202(1): 40.e1-7, 2010 Jan.
Article in English | MEDLINE | ID: mdl-19762001

ABSTRACT

OBJECTIVE: The purpose of this study was to assess the utility of soluble vascular endothelial growth factor 1 (sVEGF R1) and placental growth factor (PlGF) levels in the clinical diagnosis of preeclampsia. STUDY DESIGN: Plasma was collected prospectively from 457 subjects (n = 409 without preeclampsia, n = 48 with preeclampsia) at 20-36 weeks' gestation. Automated immunoassays were used to measure free sVEGF R1 and free PlGF. RESULTS: Clinical sensitivities of 0.96 and specificities of 0.96 and 0.95 were calculated for sVEGF R1 and PlGF, respectively, for aiding in the diagnosis of preeclampsia. Among subjects with chronic hypertension, sVEGFR1 was dramatically elevated and PlGF decreased in those with superimposed preeclampsia (P < .001 for superimposed preeclampsia vs chronic hypertension for both biomarkers). The ratio of sVEGFR1/PlGF provided a better test to aid in the diagnosis of preeclampsia than either analyte alone (3% false positive rate). CONCLUSION: Free sVEGF R1 and PlGF were useful in differentiating women with preterm preeclampsia from normotensive and hypertensive subjects.


Subject(s)
Immunoassay/methods , Pre-Eclampsia/diagnosis , Pregnancy Proteins/blood , Vascular Endothelial Growth Factor Receptor-1/blood , Female , Humans , Placenta Growth Factor , Pregnancy , Prospective Studies , ROC Curve , Sensitivity and Specificity
5.
Obstet Gynecol ; 114(2 Pt 2): 482-484, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19622970

ABSTRACT

BACKGROUND: Urinothorax is defined as the presence of urine in the pleural cavity. This condition is due to the leakage of urine from the peritoneal and retroperitoneal space into the pleural space. We report a case of urinothorax after total abdominal hysterectomy. CASE: A premenopausal woman underwent total abdominal hysterectomy and left salpingo-oophorectomy for pelvic pain, requiring extensive dissection. Her postoperative course was complicated by right urinothorax, which was diagnosed after a diagnostic thoracocentesis and resolved after a therapeutic thoracocentesis and the repair of the urinary bladder rent. CONCLUSION: Urinothorax can occur in cases of undiagnosed urinary tract injury. It presents as postoperative shortness of breath and pleural effusion and should be considered in the differential diagnosis.


Subject(s)
Hydrothorax/etiology , Hysterectomy/adverse effects , Urinary Bladder/injuries , Urine , Female , Humans , Hydrothorax/diagnosis , Hydrothorax/therapy , Premenopause
6.
Obstet Gynecol ; 109(2 Pt2): 541-3, 2007 Feb.
Article in English | MEDLINE | ID: mdl-17267888

ABSTRACT

BACKGROUND: Pseudomembranous colitis due to Clostridium difficile infection is rarely reported in the obstetric literature. This disease process is associated with prior antibiotic exposure. CASE: A term primigravida was delivered by primary cesarean for failed vacuum extraction. She received Intravenous cefazolin after cord clamping, which was continued for 36 hours for a presumptive diagnosis of endometritis. On day 3, oral amoxicillin and clavulanate was started for suspected cellulitis of the incision. She was readmitted 1 day after her discharge with severe diffuse abdominal pain and distention. Proctoscopy showed pseudomembranous colitis. Colectomy with temporary ileostomy was performed for worsening symptoms and imminent perforation. CONCLUSION: The diagnosis of pseudomembranous colitis should be considered in postpartum women who have low-grade fever, abdominal and gastrointestinal symptoms, and recent antibiotic exposure.


Subject(s)
Clostridioides difficile , Enterocolitis, Pseudomembranous/diagnosis , Postoperative Complications/diagnosis , Puerperal Disorders/diagnosis , Adult , Anti-Bacterial Agents/therapeutic use , Cesarean Section , Colectomy , Combined Modality Therapy , Diagnosis, Differential , Enterocolitis, Pseudomembranous/drug therapy , Enterocolitis, Pseudomembranous/pathology , Enterocolitis, Pseudomembranous/surgery , Female , Humans , Ileostomy , Infant, Newborn , Postoperative Complications/drug therapy , Postoperative Complications/pathology , Postoperative Complications/surgery , Pregnancy , Puerperal Disorders/drug therapy , Puerperal Disorders/pathology , Puerperal Disorders/surgery , Vacuum Extraction, Obstetrical
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