1.
Chem Commun (Camb)
; 51(44): 9201-4, 2015 Jun 04.
Article
in English
| MEDLINE
| ID: mdl-25952163
ABSTRACT
This paper describes the direct synthesis of pyrazoles from esters that comprises two sequential reactions: tert-butoxide-assisted C-C(=O) coupling reaction to yield ß-ketonitrile or α,ß-alkynone intermediates, and condensation by hydrazine addition. The method reported allows for easy control of the regioselectivity and structure of substituents at N-1, C-3, C-4 and/or C-5 positions.