1.
Bioorg Med Chem Lett
; 22(17): 5545-9, 2012 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-22850208
ABSTRACT
Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of ß-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.