ABSTRACT
Enzyme activities in the circulating lymphocytes permit to judge the character of the regenerative process in the lung, and the severity of the patient's condition; it helps in estimating the prognosis and in evaluating the efficacy of the applied therapy. Potassium orotate and Riboxin intensify the regenerative process in the lung undergoing a compensatory-hypertrophic rearrangement, and enhance the functional activity of circulating lymphocytes as participants of the regenerative process and stimulate the oxidation-reduction processes in lymphocytes.
Subject(s)
Lung/physiology , Lymphocytes/enzymology , Purines/pharmacology , Pyrimidines/pharmacology , Regeneration/drug effects , Acid Phosphatase/blood , Alkaline Phosphatase/blood , Animals , Glycerolphosphate Dehydrogenase/blood , Humans , Hypertrophy/enzymology , Inflammation/drug therapy , Inosine Diphosphate/pharmacology , Inosine Diphosphate/therapeutic use , L-Lactate Dehydrogenase/blood , Lung/pathology , Lymphocyte Activation/drug effects , Male , Neutrophils/enzymology , Orotic Acid/pharmacology , Orotic Acid/therapeutic use , Purines/therapeutic use , Pyrimidines/therapeutic use , Rats , Succinate Dehydrogenase/blood , Uracil/analogs & derivatives , Uracil/therapeutic useABSTRACT
It has been established that data of cytochemical investigation of leukocytes can show the severity of the pathological process and contribute to prognosing further development of pyo-inflammatory disease. Pyrimidine derivatives have a pronounced normalizing effect on the enzyme activity of leukocytes.
Subject(s)
Abscess/enzymology , Cellulitis/enzymology , Glycerolphosphate Dehydrogenase/blood , Leukocytes/enzymology , Mastitis/enzymology , Pyrimidines/pharmacology , Succinate Dehydrogenase/blood , Abscess/drug therapy , Cellulitis/drug therapy , Female , Humans , Mastitis/drug therapy , Pregnancy , Prognosis , Pyrimidines/therapeutic use , SuppurationABSTRACT
The effect of orotic acid on the development of compensatory pulmonary hypertrophy has been studied in the clinic and in the experiments (71 patients, and 349 rats) carried out with the use of morphologic, biochemical cytochemical, immunologic and clinical methods, and also through autoradiography. The results of the study prove the effect of the drug upon the pulmonary regeneration. Experimental findings have shown that behind the stimulating effect of the drug there is the activation of the synthesis of nucleinic acids, the rise of the mitotic activity of the interalveolar membranes cells of the lung remnants. An essential increase of the lymphocytic dehydrogenase activity of the peripheral blood occurred in response to the effect of the drug.
