ABSTRACT
BACKGROUND AND PURPOSE: Stroke, a severe and recurrent but preventable complication of sickle cell disease (SCD), has not been well studied in Cameroon. To obtain baseline data towards the development of a national stroke prevention programme in SCD, we studied a sample of sickle cell patients with the aim of determining stroke prevalence, clinical presentation and management practices. PATIENTS AND METHODS: Homozygous sickle cell patients in two centres in Yaounde were screened for stroke, in a cross-sectional study. Stroke was diagnosed clinically and confirmed where possible with brain computerized tomography. The National Institutes of Health Stroke Score (NIHSS) and modified Rankin scale (mRS) were used to assess stroke severity. Management practices were noted from patient charts. RESULTS: One hundred and twenty patients aged 7 months to 35 years (mean age 13.49+/-8.79 years) were included. Eight cases of stroke (mean age 16.6+/-11.2 years) were identified, giving a stroke prevalence of 6.67%. Cerebral infarction was thrice as common as cerebral hemorrhage and clinical presentation was classical. Cerebral infarction was more frequent in patients aged below 20 years and hemorrhage in those above 20 (p=0.11). The annual recurrence rate was 25%. Missed diagnosis rate by attending physician was 25%. The NIHSS and mRS showed high stroke severity. Stroke management practices were insufficient and no patient received any form of stroke prophylaxis. CONCLUSION: Stroke prevalence and presentation in sickle cell patients in Yaounde is similar to that observed in developed countries, but the wide management gap calls for rapid action. Our situation is ideal for the study of the natural history of stroke in sickle cell disease.
Subject(s)
Anemia, Sickle Cell/epidemiology , Stroke/epidemiology , Adolescent , Adult , Cameroon/epidemiology , Cerebral Hemorrhage/epidemiology , Cerebral Infarction/epidemiology , Child , Child, Preschool , Comorbidity , Cross-Sectional Studies , Diagnostic Errors/statistics & numerical data , Disability Evaluation , Female , Humans , Infant , Male , Prevalence , Quality of Health Care/statistics & numerical data , Quality of Health Care/trends , Secondary Prevention , Stroke/physiopathology , Stroke/therapyABSTRACT
52 cases of laryngeal papillomatosis are found in Cameroun during a 6 1/2 year period (1st January 84-30th June 90). The 52 patients are 27 men and 25 women aged 10 months to 65 years. 40 patients (77%) are less than 15 years and present with the juvenile form of laryngeal papillomatosis. Clinically, all the patients have dysphonia and 30% of them complain of dyspnoea. Less frequent symptoms are cough, foreign body sensation in the throat, dysphagia. Endoscopic and histologic aspects of the disease are those classically described.
