1.
J Org Chem
; 81(21): 10160-10164, 2016 11 04.
Article
in English
| MEDLINE
| ID: mdl-27454875
ABSTRACT
Diethylzinc-mediated metalloamination/cyclization of unsaturated N,N-dimethylhydrazines has been extended to the use of 1,2-disubstituted alkenes as N-Zn migratory insertion acceptors. Representative 2-arylethenes and vinylcyclopropanes readily serve as reaction participants in metalloamination/cyclization-allylation cascades.
2.
Angew Chem Int Ed Engl
; 53(52): 14352-6, 2014 Dec 22.
Article
in English
| MEDLINE
| ID: mdl-25302713
ABSTRACT
Highly diastereoselective metalloamination/cyclization reactions of zinc(II) hydrazides obtained through reaction of diethylzinc with N,N-dimethylhydrazinoalkenes are described. The resulting organozinc intermediates undergo facile allylation and acylation, in situ, to provide the corresponding functionalized piperidines and pyrrolidines.