ABSTRACT
Objective:To investigate the sensitization characteristics of ragweed pollen in patients with allergic rhinitisï¼ARï¼ andï¼orï¼ allergic asthma in Beijing area, and to provide basis for the prevention and treatment of ragweed pollen sensitized population. Methods:Patients with allergic rhinitis and/or asthma from January 2017 to December 2019 in the outpatient department of Allergy Department of Beijing Shijitan Hospital were retrospectively analyzed in this study. Skin prick testï¼SPTï¼ was performed with ragweed pollen allergen reagents to compare different ages, genders and respiratory diseases allergen distribution, and to observe the sensitization characteristics of its population. All of the analyses were performed using SAS software version 9.4. Results:A total of 9 727 patients were enrolled in the end. The total positive rate of ragweed pollen SPT was 45.50%ï¼4 426/9 727ï¼, the highest positive rate was 65.54% in 13-17 years old group; The positive rate of ragweed pollen SPT was 49.79% in allergic rhinitis combined with asthma patients, followed by 46.46% in allergic rhinitis patients, and the lowest rate was 19.42% in single allergic asthma patients. There were more females than males in both ragweed pollen sensitized and non-ragweed pollen sensitized groupsï¼P<0.05ï¼, and the proportion was higher in 30-39 years old than in other age groupsï¼P<0.05ï¼. Ragweed pollen sensitization was higher than non-ragweed pollen sensitization in the allergic rhinitis groupï¼98.49% vs 94.76%, P<0.05ï¼. Ragweed pollen with other summer and autumn pollen allergens in patients with positive SPT, the top three were Chenopodium pollen, Humulus pollen and Artemisia grandis pollen, with positive rates of 90.42%, 89.63% and 85.40%, respectively. Ragweed combined with other pollen sensitization accounted for 99.57%ï¼4 407/4 426ï¼. Allergic rhinitis was the main disease in patients sensitized with ragweed pollen alone or combined with other pollens, and there was no significant difference between the two groupsï¼94.97% vs 98.50%, P>0.05ï¼. Conclusion:Ragweed pollen is highly sensitized in Beijing area, single ragweed pollen sensitization is rare, often combined with multiple pollen sensitization, and allergic rhinitis is the main disease.
Subject(s)
Asthma , Rhinitis, Allergic, Seasonal , Rhinitis, Allergic , Humans , Male , Female , Adolescent , Adult , Rhinitis, Allergic, Seasonal/epidemiology , Retrospective Studies , Allergens , Pollen , Asthma/epidemiology , Skin TestsABSTRACT
Objective:To investigate the sensitization characteristics of cockroach in patients with allergic rhinitisï¼ARï¼ and/or allergic asthma in Beijing area, and to provide basis for the prevention and treatment of cockroach sensitized population. Methods:Clinical data of patients with allergic rhinitis and/or asthma from January 2017 to December 2019 treated in the outpatient Department of Allergy of Beijing Shijitan Hospital were retrospectively analyzed.Skin prick test ï¼SPTï¼ was performed with cockroach allergen reagents. The cockroach sensitization of patients with different ages and diseases was compared, and the population distribution characteristics of cockroach sensitization were observed.Statistical analysis was performed using SAS 9.4 software. Results:A total of 9915 patients were enrolled in the end.The total positive rate of cockroach SPT was 24.79%ï¼2458/9915ï¼,with the highest positive rate ï¼31.65%ï¼ in 15-19 years old group. The positive rate of SPT increased with age in patients less than 14 years old, while the positive rate of SPT was basically flat with age in patients more than 20 years old .The positive rate of cockroach SPT was 24.83% ï¼2355/9484ï¼ in allergic rhinitis patients,26.38% ï¼410/1554ï¼ in allergic asthma patients, and 27.34% ï¼307/1123ï¼ in allergic rhinitis combined with asthma patients. Single cockroach SPT positive accounted for 9.64% ï¼237/2458ï¼, cockroach with other indoor inhalation allergens SPT positive accounted for 90.36% ï¼2221/2458ï¼. The positive SPT rates for combined Der f , Der p,house dust, cat dander, and dog dander were 74.25% ï¼1825/2458ï¼, 66.27% ï¼1629/2458ï¼, 58.99% ï¼1450/2458ï¼, 43.08% ï¼1059/2458ï¼, and 40.85% ï¼1004/2458ï¼, respectively.In allergic rhinitisï¼asthmaï¼and allergic rhinitis combined with asthmaï¼the cockroach SPT positive rate was higher in the adult group than that in juvenile groupï¼and the difference of positive rate in allergic rhinitis group was statistically significantï¼25.81% vs 19.07%, P<0.001ï¼.In the juvenile group, the positive rate of SPT in AR combined with asthma was higher than that in AR and that in asthma. Conclusion:Cockroach allergy in patients with AR and/or allergic asthma in Beijing is relatively high, most of them are sensitized by multiple inhalation allergens, and the sensitization degree of adults is higher than that of juvenile.