[Drug treatment of gestational arterial hypertension in medical institutions of Russia (population study)]. / Lekarstvennaia terapiia arterial'noi gipertonii u beremennykh v lechebnykh uchrezhdeniiakh Rossii (populiatsionnoe issledovanie).

AIM: To evaluate current situation with administration of drugs against gestational arterial hypertension (GAH) in medical institutions of Russia. MATERIALS AND METHODS: A population study in representative territories of European Russia has been performed to investigate current practice of GAH chemotherapy as compared to chronic arterial hypertension (CAH). RESULTS: In spite of shorter duration, GAH treatment employed two times greater amount of medicines per a course than chemotherapy of CAH. Injections and infusions were practiced in GAH 4.6 and 4.3 times more frequently than in CAH, respectively. Most popular drugs for injection were spasmolytics dibasol, papaverin solution, magnesium sulphate solution, for oral administration--clonidin. Specific antihypertensive medicines and beta-blockers dominated in CAH; infusions, sedatives and diuretics were used less frequently. In GAH infusions of plasma substitutes was widely practiced without adequate antihypertensive treatment. CONCLUSION: Management of pregnant women with hypertension overuses medicines. However, new effective antihypertensive medicines are not infrequently ignored. This fact can provoke further elevation of blood pressure and eventually result in preterm delivery. It is necessary to develop national standard of drug treatment of pregnant women with hypertension.

[Gestational arterial hypertension: clinico-epidemiological study]. / Arterial'naia gipertoniia u beremennykh: kliniko-épidemiologicheskoe issledovanie.

AIM: Epidemiological assessment of prevalence of blood hypertension (BH) in pregnant women. MATERIALS AND METHODS: Blood pressure and urinary protein were measured in 5160 gravidae observed in female consultations in 4 cities of Russia. RESULTS: BH was found in 1042(20.2%) examinees. Chronic BH was diagnosed in 306 patients. The rest females had gestational BH. Essential hypertension occurred in 174 patients. CONCLUSION: A stable rise of diastolic blood pressure above 90 mm Hg is a reliable diagnostic criterion of hypertension in gravidae. Classic proteinuric forms of gestational BH are rare.

[The pharmacokinetics and pharmacodynamics of trental in pregnant women with chronic placental insufficiency]. / Farmakokinetika i farmakodinamika trentala u beremennykh s khronicheskoi platsentarnoi nedostatochnost'iu.

Examining the relationship between the pharmacokinetic characteristics of trental, its effect on platelet aggregation and adverse effects in pregnant females with chronic placental failure has allowed the optimal dosage regimen to be recommended in the third trimester in this abnormality. Its daily dose was found to be 400 mg (100 mg x 4).

[The pharmacokinetics and pharmacodynamics of pentoxifylline (trental) in the third pregnancy trimester]. / Farmakokinetika i farmakodinamika pentoksifillina (trentala) v III trimestre beremennosti.

As a result of studies into the pharmacokinetics of pentoxyfillin, no significant differences were established in the magnitudes of its non-model parameters in normal pregnancy and chronic placental insufficiency. However, there were differences in the metabolite formation rate in the groups under study. Distinctions were detected in the antiaggregation effect of pentoxyfillin. They consisted in a slower recovery of platelet aggregation parameters to the initial values in the first group examined. There was no good agreement between the concentrations of pentoxyfillin, its major pharmacologically active metabolite in blood plasma of pregnant women and the antiaggregation effect, which reaffirms the indirect action of this drug on platelets.