Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Trends Cell Biol ; 25(5): 249-64, 2015 May.
Article in English | MEDLINE | ID: mdl-25592806

ABSTRACT

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.


Subject(s)
Bone Morphogenetic Proteins/antagonists & inhibitors , Intercellular Signaling Peptides and Proteins/chemistry , MicroRNAs/chemistry , Signal Transduction , Animals , Gene Expression Regulation , Humans , Mice , Protein Binding , Protein Structure, Tertiary , Sequence Homology, Amino Acid
SELECTION OF CITATIONS
SEARCH DETAIL
...