ABSTRACT
PGI2 was found to increase the number of free platelets (FP) in citrated whole blood (WB) as a result of incomplete dispersion of platelet aggregates of various magnitudes. In WB from young, male volunteers the effect of PGI2 on FP number was absent immediately after blood collection, increased with time of blood storage, and was dose-dependent. In WB from 14 males with myocardial infarction (MI) effect of PGI2 on FP number was higher than in 11 male patient controls (PC). On 14th day after MI effect of PGI2 on FP in WB was reduced. It is concluded that measurement of PGI2-sensitive platelet aggregates may be of some clinical significance. However, presented results did not allow for differentiation between circulating platelet aggregates and those formed in vitro during spontaneous aggregation of platelets.
Subject(s)
Epoprostenol/pharmacology , Myocardial Infarction/physiopathology , Platelet Aggregation/drug effects , Humans , Male , Reference ValuesABSTRACT
On December 6, 1979, three luncheon banquets were served in a New Jersey restaurant. Thirty-eight of 41 members (92.7%) of the first group became ill as did 25 of 31 members (80.6%) of the second group. None of 12 members of the third group were ill. Illness consisted primarily of diarrhea (76%), nausea, (73%), vomiting (67%), cramps (46%) and fever (18%); the median incubation period was 31 hours and median duration 24 hours. The same foods were served to all three groups, except that cole slaw was substituted for a green salad and mixed vegetables for lima beans for the third group. Consumption of green salad was associated with illness (p less than 0.0001). A total of 118 other persons who ate at the restaurant on the same day were interviewed, 60% of whom reported being ill. Green salad was significantly associated with illness for this group at lunch (p = 0.005) and dinner (p = 0.00007). Serologic studies on seven of 12 patients and on one of four exposed controls showed a fourfold or greater rise in antibody titer to Norwalk virus.
