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2.
Farmakol Toksikol ; 48(4): 103-5, 1985.
Article in Russian | MEDLINE | ID: mdl-4043357

ABSTRACT

On the third day after a single administration of nitrosodimethylamine (30 mg/kg) to white rats histochemistry reveals the greatest injury to the liver parenchyma. This correlates with a reduction in relative strength of intercellular contacts, an increase in relative strength of the membranes, and an elevation of the membrane potential during liver tissue survival in vitro. The latter fact can be explained, at any rate partially, by the lowering of the activity of cytoplasmic ATPase which competes with electrogenic Na+. K+-ATPase for ATP.


Subject(s)
Dimethylnitrosamine/toxicity , Liver/drug effects , Animals , Biophysical Phenomena , Biophysics , Cell Membrane/drug effects , Intercellular Junctions/drug effects , Liver/cytology , Liver/enzymology , Male , Membrane Potentials/drug effects , Rats , Time Factors
3.
Arkh Anat Gistol Embriol ; 88(2): 72-6, 1985 Feb.
Article in Russian | MEDLINE | ID: mdl-3994530

ABSTRACT

Under the influence of atmospheric pollutions certain structural-functional changes take place in placenta: terminal villi per stipulated square unite, villi with desquamated epithelium, with dilated vessels, with deposition of fibrinoid masses, with plasmodial buds increase in number; section area occupied by epithelial layer decreases; RNA concentration and histoenzymatic activity change in the latter.


Subject(s)
Air Pollutants/poisoning , Placenta Diseases/chemically induced , Placenta/pathology , Adolescent , Adult , Carbon Monoxide Poisoning/complications , Dust/adverse effects , Female , Humans , Organ Size , Phenol , Phenols/poisoning , Placenta Diseases/enzymology , Pregnancy , Trophoblasts/enzymology
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