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Bioorg Med Chem Lett ; 10(14): 1501-3, 2000 Jul 17.
Article in English | MEDLINE | ID: mdl-10915036

ABSTRACT

A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/micromol.


Subject(s)
Fluorine Radioisotopes , Oligopeptides/chemical synthesis , Tomography, Emission-Computed , Acylation , Amino Acid Sequence , Benzoates , Indicators and Reagents , Isotope Labeling/methods , Oligopeptides/chemistry
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