[CHEMICAL COMPONENTS FROM STEMS ASTRAGALUS FALCATUS, GROWING IN GEORGIA].

Astragalus falcatus is the source of medicinal remedy Flaroninum, also other biologically active substances. Eight compounds were isolated and identified from the of stems : calycosin-7-O- ß -D - glucoside, isoquercitrin (quercetin-3-O - ß -D- glucoside), astragalin (kaempferol-3-O - ß -D- glicoside), robinin (kaempferol-3- O- ß -D- robinobiosyl, 7- O- a-L-rhamnoside), ß - sitosterin, p-hydroxibenzoic acid, sulfuretin and isoliquiritigenin. These compounds were described for the first time from the stems of Astragalus falcatus.

[RESULTS OF THE PRELIMINARY STUDY OF PLANTS OF GEORGIAN FLORA FOR THE CONTENT OF FLAVONOIDS AND TRITERPENOIDS].

The aim of the study was a preliminary study of plant samples collected by targeted expeditions of the department of pharmacobotany (Department of Phytochemistry) of the IG Kutateladze Institute of Pharmacochemistry for the period 2016-2017. In total, 341 objects from (106 various) plants belonging to 36 families and 93 genus were analyzed. The objects were obtained polar and non-polar fractions; flavonoids and triterpenoids were found in them qualitatively. To characterize used P /CH and TLC analysis in various solvent systems. Flavonoids were isolated from Geranium ibericum and Polygonum carneum, which were identified as quercetin-3-0-ß-D-galactopyranoside-hyperin (G. ibericum), 3 5, 7 ', 3'.4' pentahydroxy-flavone - quercetin (G. ibericum, P. сarneum) and quercetin-3-0-rutinozide - rutin (P. сarneum). G. ibericum and P.carneum flora of Georgia are found and studied for the first time. Representatives of the family Asteraceae, Fabaceae, Helleboraceae, Polygonaceae, Scrophula riaceae deserve a particular interest in the content of triterpenoids.

[Study of antioxidant activity of phenolic compounds from some species of Georgian flora].

The antioxidant activity of extracts obtained from different parts of Georgian flora species Hamamelis virginiana L., Astragalus caucasicus Pall., Astragalus microcephalus Willd., Vitis vinifera L., Rhododendron ponticum L., Rhododendron Ungernii Trautv., Ginkgo biloba L., Salvia officinalis L., Querqus iberica Stev., Maclura aurantiaca Nutt., Cotinus coggygria Ledeb., Fraxinus ornus L., Urtica dioica L., Rhododendron caucasicum Pall., Pueraria hirsuta Matsum., Geranium pusillum L., Astragalus Tanae Sosn., Pinus silvestris L. has been studied. Comparison with ethylentetraacetate and α-tocopherole revealed high efficacy of all extracts studied. 45 individual phenolic compounds were isolated and described by chemical examination of biologically active objects. Common sage (Salvia officinalis) extract turned out as the most active (200 %). The chemical study revealed the dominant content of condensed tannins and low molecular phenolic compounds, which may be attributed to the high antioxidant activity. Biologically active antiatherosclerotic food additive "Salbin" was developed on the basis of Common sage - Salvia officinalis L. phenolic compounds.