ABSTRACT
Polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) improved peripheral blood supply, normalized the overall oxygen consumption, decreased erythrocyte aggregation, and reduced blood viscosity at low shear rate, and restored the antiturbulent properties (hydrodynamic index) of blood in the experiments on rats with crush syndrome. In rats with low resistance, polyetox increased the cardiac output.
Subject(s)
Crush Syndrome/physiopathology , Hemodynamics/drug effects , Hemorheology/drug effects , Polyethylene Glycols/pharmacology , Animals , Blood Viscosity/drug effects , Crush Syndrome/blood , Erythrocyte Aggregation/drug effects , Male , Oxygen Consumption/drug effects , Rats , Regional Blood Flow/drug effectsABSTRACT
Experiments on narcotized rats with crush syndrome showed that low resistant animals developed pronounced hypovolemia, hemoconcentration, blood hyperviscosity, impairment of oxygen metabolism, and central and peripheral hemodynamic disturbances, whereas in highly resistant rats the hemodynamics and oxygen supply to tissues were maintained at a sufficient level, while hemoconcentration and the increase in blood viscosity were less pronounced.
Subject(s)
Crush Syndrome , Shock , Animals , Dose-Response Relationship, Drug , Hemodynamics , Hypovolemia , Male , Oxygen/metabolism , RatsABSTRACT
Narcotized rats with crush syndrome develop severe syndrome of increased blood viscosity. A strict correlation was found between changes in blood viscosity at different shear rates and total peripheral vascular resistance. The severity of central hemodynamic and hemorheological disturbances was different in rats with different reaction of total peripheral vascular resistance to injury accompanied by shock.
